An Unveiling the Enigma: Case Series of Retroperitoneal Tumors and literature review
Case Series of Retroperitoneal Tumors and literature review
Keywords:
Retroperitoneal tumors, Malignant, hypochondrial pain, metastatic arm swelling.
Abstract
Introduction: Retroperitoneal tumours (RPTs) are a diverse group of lesions that arise in the retroperitoneum and pelvic space. The histological spectrum of retroperitoneal masses is broad, ranging from major aggressive malignancies to benign lesions.
Objective: This case series and literature review aimed to study the incidence of retroperitoneal tumours presenting in a diverse array encountered in clinical practice, diagnosed on cytology or biopsy.
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References
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9. Choi J.H., Ro J.Y. Retroperitoneal sarcomas: an update on the diagnostic pathology approach. Diagnostics. 2020 Sep;10(9):642. doi: 10.3390/diagnostics10090642.
10. AlRashed R, AlHarbi H, Abdulfattah F, Alhasan I, Alsannaa F. A case report of retroperitoneal Ewing sarcoma requiring adrenalectomy. Int J Surg Case Rep. 2022 Jun;95:106966. doi: 10.1016/j.ijscr.2022.106966. Epub 2022 Apr 11.
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13. Hu HJ, Liao MY, Xu LY. Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. Oncol Lett. 2014 Jun;7(6):1970-1974. doi: 10.3892/ol.2014.2012. Epub 2014 Mar 28. PMID: 24932271; PMCID: PMC4049765.
14. Katabuchi H, Honda R, Tajima T, Ohtake H, Kageshita T, Ono T, Okamura H. Clear cell sarcoma arising in the retroperitoneum. Int J Gynecol Cancer. 2002 Jan-Feb;12(1):124-7. doi: 10.1046/j.1525-1438.2002.01052.x. PMID: 11860547.
15. Sarra Ben Rejeb, Safia Sakly, Majdi Ben Romdhane, Mehdi Charfi, Adnen Chouchen,Primary retroperitoneal synovial sarcoma (RSS): A case report, International Journal of Surgery Case Reports,Volume 127,2025,110982,ISSN 2210-2612,
16. Ansari Djafari A, Razzaghi M, Rakhshan A, Faraji S, Rahavian AH, Hojjati SA. A Large Primary Retroperitoneal Synovial Sarcoma: A Case Report of a Huge Malignant Tumor. Iran J Med Sci. 2022 May;47(3):280-284. doi: 10.30476/IJMS.2021.90470.2141. PMID: 35634528; PMCID: PMC9126900.
17. Aktaş H, Işık Ö, Emiroğlu R. Solid pseudopapillary tumor of the pancreas: A case report. Turk J Surg.2020 Mar 18;36(1):110-112. doi: 10.5578/turkjsurg.3237. PMID: 32637883; PMCID: PMC7315450.
18. Paluri RK, John TA, Anastasopoulou C, et al. Solid Pseudopapillary Epithelial Neoplasm (SPEN) of the Pancreas. [Updated 2024 Jan 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
19. Chen L, Yuan M, Wang M, Luo C, Gao M, Huang Q, Li Z, Zhou Z. Case report: Retroperitoneal solid pseudopapillary neoplasm associated with multiple hepatic metastases. Front Oncol. 2024 Jan 30;14:1335930. doi: 10.3389/fonc.2024.1335930. PMID: 38352895; PMCID: PMC10861742.
20. Rey Chaves CE, Ayala D, García G, Conde Monroy D, Sabogal Olarte JC. Retroperitoneal pheochromocytoma: Unsual presentation and atypical location. Int J Surg Case Rep. 2021 Aug;85:106248. doi: 10.1016/j.ijscr.2021.106248. Epub 2021 Jul 27. PMID: 34352621; PMCID:
21. Ramnani S, Chawla S, Utaal MS, Singh M, Adlakha D, Thakor M.A rare case of extra adrenal retroperitoneal paraganglioma: case report.Int Surg J2024;11:644-8.
22. Ghantous I, Najjar A, Tlaiss Y, Danaf S, Chouairy CJ. Resection of Retroperitoneal Extra-Adrenal Pheochromocytoma: A Case Report. Cureus. 2023 Aug 9;15(8):e43185. doi: 10.7759/cureus.43185. PMID: 37692674; PMCID: PMC10485873.
23. Schieda N, Davenport MS, Krishna S, et al. Bosniak classification of cystic renal masses, version 2019: a pictorial guide to clinical use. Radiographics 2021;41:814–828.
24. Murshed KA, Akhtar M, Ben-Gashir M. Multilocular cystic renal neoplasm of low malignant potential extending into the perinephric adipose tissue. Hum. Pathol.: Case Rep. 019;17:200305.
25. Jadhav SP, Ali F, Kadam S,Chopra AK, Iyer VS. Intraductal papillary mucinous neoplasm in a 26 year old lady: a diagnostic therapeutic challenge! Int Surg J 2022;9:746-8.
2.V Renuka I, Vaishnavi R, Sankar Naik B, Premalatha P, Ramya C. Rare tumors of retroperitoneum- A diagnostic challenge. IJPO. 2019 Nov28;6(4):671–6.
3. Telagavi KU, Bhavikatti BM, Reddy P.A Nine Years Histopathological Retrospective Study of Retroperitoneal Masses. J Clin of Diagn Res.2022; 16(7):EC08EC12.
4. Das A, Gahine R, Patre V, Hussain N. Retroperitoneal tumor: A silent trespasser role of image-guided fine-needle aspiration cytology with histopathological correlation in early diagnosis. Acta Cytologica. 2019;63(3):189-97.
5. Kozak O, Turzyński P, Markiet K, Pieńkowska J, Skrobisz-Balandowska K, Studniarek M. Uncharacteristic metastasis of a renal clear-cell carcinoma to the muscles of the forearm—case report. BJR|case reports. 2017Sep;3(3):20150495.
6.Walton J, Li J, Clifton MM, Mori RL, Park AM, Sumfest JM. Metastatic clear cell renal cell carcinoma to the forearm without identifiable primary renal mass. Urol Case Rep. 2019 Aug 6;27:100989. doi: 10.1016/j.eucr.2019.100989. PMID: 31440453; PMCID: PMC6699464.
7. S Alvi, O Karadaghy, M Manalang, R. Weatherly Clinical manifestations of neuroblastoma with head and neck involvement in children Int J Pediatr Otorhinolaryngol, 97 (2017), pp. 157-162, 10.1016/j.ijporl.2017.04.013
8. Mousa AH, Baothman A, Alsayed AW, Rozan A, Ghannam YJ, Ibrahim A, Mostafa AF. Metastatic neuroblastoma presenting without a primary tumor: A case report. Radiol Case Rep. 2022 Apr 13;17(6):2137-2141. doi: 10.1016/j.radcr.2022.03.083. PMID: 35464796; PMCID: PMC9024373.
9. Choi J.H., Ro J.Y. Retroperitoneal sarcomas: an update on the diagnostic pathology approach. Diagnostics. 2020 Sep;10(9):642. doi: 10.3390/diagnostics10090642.
10. AlRashed R, AlHarbi H, Abdulfattah F, Alhasan I, Alsannaa F. A case report of retroperitoneal Ewing sarcoma requiring adrenalectomy. Int J Surg Case Rep. 2022 Jun;95:106966. doi: 10.1016/j.ijscr.2022.106966. Epub 2022 Apr 11.
11. Wu, SY., Hsu, CK., Yue, CT. et al. Large retroperitoneal extraskeletal Ewing’s sarcoma with renal pedicle invasion: a case report. BMC Urol 23, 95 (2023).
12. Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M, Kimura T. Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells. PLoS One. 2012;7(5):e36682. doi: 10.1371/journal.pone.0036682. Epub 2012 May 3. PMID: 22570737; PMCID: PMC3343026.
13. Hu HJ, Liao MY, Xu LY. Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. Oncol Lett. 2014 Jun;7(6):1970-1974. doi: 10.3892/ol.2014.2012. Epub 2014 Mar 28. PMID: 24932271; PMCID: PMC4049765.
14. Katabuchi H, Honda R, Tajima T, Ohtake H, Kageshita T, Ono T, Okamura H. Clear cell sarcoma arising in the retroperitoneum. Int J Gynecol Cancer. 2002 Jan-Feb;12(1):124-7. doi: 10.1046/j.1525-1438.2002.01052.x. PMID: 11860547.
15. Sarra Ben Rejeb, Safia Sakly, Majdi Ben Romdhane, Mehdi Charfi, Adnen Chouchen,Primary retroperitoneal synovial sarcoma (RSS): A case report, International Journal of Surgery Case Reports,Volume 127,2025,110982,ISSN 2210-2612,
16. Ansari Djafari A, Razzaghi M, Rakhshan A, Faraji S, Rahavian AH, Hojjati SA. A Large Primary Retroperitoneal Synovial Sarcoma: A Case Report of a Huge Malignant Tumor. Iran J Med Sci. 2022 May;47(3):280-284. doi: 10.30476/IJMS.2021.90470.2141. PMID: 35634528; PMCID: PMC9126900.
17. Aktaş H, Işık Ö, Emiroğlu R. Solid pseudopapillary tumor of the pancreas: A case report. Turk J Surg.2020 Mar 18;36(1):110-112. doi: 10.5578/turkjsurg.3237. PMID: 32637883; PMCID: PMC7315450.
18. Paluri RK, John TA, Anastasopoulou C, et al. Solid Pseudopapillary Epithelial Neoplasm (SPEN) of the Pancreas. [Updated 2024 Jan 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
19. Chen L, Yuan M, Wang M, Luo C, Gao M, Huang Q, Li Z, Zhou Z. Case report: Retroperitoneal solid pseudopapillary neoplasm associated with multiple hepatic metastases. Front Oncol. 2024 Jan 30;14:1335930. doi: 10.3389/fonc.2024.1335930. PMID: 38352895; PMCID: PMC10861742.
20. Rey Chaves CE, Ayala D, García G, Conde Monroy D, Sabogal Olarte JC. Retroperitoneal pheochromocytoma: Unsual presentation and atypical location. Int J Surg Case Rep. 2021 Aug;85:106248. doi: 10.1016/j.ijscr.2021.106248. Epub 2021 Jul 27. PMID: 34352621; PMCID:
21. Ramnani S, Chawla S, Utaal MS, Singh M, Adlakha D, Thakor M.A rare case of extra adrenal retroperitoneal paraganglioma: case report.Int Surg J2024;11:644-8.
22. Ghantous I, Najjar A, Tlaiss Y, Danaf S, Chouairy CJ. Resection of Retroperitoneal Extra-Adrenal Pheochromocytoma: A Case Report. Cureus. 2023 Aug 9;15(8):e43185. doi: 10.7759/cureus.43185. PMID: 37692674; PMCID: PMC10485873.
23. Schieda N, Davenport MS, Krishna S, et al. Bosniak classification of cystic renal masses, version 2019: a pictorial guide to clinical use. Radiographics 2021;41:814–828.
24. Murshed KA, Akhtar M, Ben-Gashir M. Multilocular cystic renal neoplasm of low malignant potential extending into the perinephric adipose tissue. Hum. Pathol.: Case Rep. 019;17:200305.
25. Jadhav SP, Ali F, Kadam S,Chopra AK, Iyer VS. Intraductal papillary mucinous neoplasm in a 26 year old lady: a diagnostic therapeutic challenge! Int Surg J 2022;9:746-8.
How to Cite
Purkayastha, P., Das, R., & Das, R. (2025). An Unveiling the Enigma: Case Series of Retroperitoneal Tumors and literature review. Tropical Journal of Pathology and Microbiology, 11(1), 5-16. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/680
Section
Case Series
Copyright (c) 2025 Author (s). Published by Siddharth Health Research and Social Welfare Society
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