Tropical Journal of Pathology and Microbiology <p><em><strong>ISSN: <a href="" target="_blank" rel="noopener">2456-1487 (Online)</a>, <a href="" target="_blank" rel="noopener">2456-9887 (Print)</a></strong></em></p> <p><em><strong>RNI: MPENG/2017/70771</strong></em></p> en-US (Mr Daulat Ram) (Mr Daulat Ram) Sun, 31 Mar 2024 00:00:00 +0530 OJS 60 Hematolymphoid Malignancies with Neurological Manifestations and Hand-mirror cells in Peripheral Blood: A Report of two cases <p>Hematolymphoid malignancies(HLM) can present with clinical features of systemic involvement and show hand-mirror cells(HMCs) in peripheral blood.</p> <p>Two-patients presented with back pain and lower-limb weakness, blood smears revealed atypical cells, HMCs and thrombocytopenia. Imaging studies showed extradural spinal lesions. Histopathology of laminectomy specimens revealed myeloid sarcoma and diffuse B-cell lymphoma.</p> <p>HMCs can be seen in malignant and non-malignant conditions. Presence of HMCs may be the initial finding in peripheral blood indicating underlying malignancy with or without generalized symptomatology and leucocytosis. This study aims to emphasize that presence of HMCs should prompt appropriate investigations and management after ruling out reactive conditions.</p> Dr Sangeetha Seshagiri Karnam Copyright (c) 2024 Author (s). Published by Siddharth Health Research and Social Welfare Society Thu, 09 May 2024 00:00:00 +0530