A study of E- Cadherin in benign and malignant breast lesions with its correlation with histopathology

Dr ravikant Verma — 2023-04-28

Introduction

Breast diseases are showing a rising trend worldwide. A number of studies have been done to show the magnitude of problem^.Various breast lesions include inflammatory lesions, benign proliferative breast diseases like firoadenosis, fibrocystic disease papillomas etc. and various cancers. Much concern is given to malignant lesions of breast. Breast cancer ranks first among malignant tumors affecting female in many part of world.

Aims And Objectives

We aimed to study correlation between histopathology and immunohistochemical analysis of E- cadherin in benign and malignant breast lesions
To study role of E- cadherin in differentiating benign verses malignant breast lesions

STUDY DESIGN- Cross-sectional study.

SAMPLE SIZE- The present study was conducted on 100 cases of breast tumors. The study was carried out to find out the histological type of lesion along with role of E-cadherin in benign and malignant breast lesions.

INCLUSION CRITERIA FOR HISTOPATHOLOGICAL EXAMINATION-Resected breast tissue specimens suspected to have benign and neoplastic lesions along with all the mastectomy specimen.

EXCLUSION CRITERIA FOR HISTOPATHOLOGICAL EXAMINATION

Inadequate tissue sample.
Autolysed tissue sample.

RESULT- Out of 100 cases studied, 22 cases were benign and 78 cases were malignant lesions.

CONCLUSION- Present study demonstrates that E-cadherin is strongly expressed in all benign breast lesions and there is increasing loss of E-cadherin expression with increasing grade/severity of malignancy.

Histologic subtypes of Meningiomas: Review and variation in an African population

Onyekachi Itohan Aniume — 2023-07-01

Background

Meningiomas are considered to be the commonest neoplasm of the central nervous system and are also the most studied meningeal tumour. According to the WHO 2020 classification of meningiomas, there are fifteen subtypes that have been grouped into grades 1, 2 and 3. The WHO grade 1 meningiomas are generally grouped as benign while the WHO grade 2 and 3 tumours are grouped as malignant. The aim of this study is to show the variation of these subtypes in relation to the age, gender and location in an African population.

Materials and Methods

A 10-year retrospective review of all histologically diagnosed Meningiomas from 1^st January, 2010 to 31^st December, 2019 is presented. The distribution of the tumour in relation to the age, sex and location was assessed in this study.

Results

The three WHO grades of meningioma were assessed in this study. The M:F ratio was 1:1.4 and peak age incidence was seen in individuals 41 – 50 years (SD ± 16.54). Majority of the cases were WHO grade 1 (86.1%) while WHO grades 2 and 3 tumours were 8% and 5.9% respectively. A slight variation in the common subtypes in males and females were observed. Fibroblastic variant was the overall commonest subtype (27.1%).

Conclusion

The diversity of the subtypes of meningiomas of meningioma calls for strict classification protocols for standardization of patients’ grouping and potentially, management. Tumour genetics of the subtypes can be explored for potential management of complicated cases.

Tropical Journal of Pathology and Microbiology

A study of E- Cadherin in benign and malignant breast lesions with its correlation with histopathology

Histologic subtypes of Meningiomas: Review and variation in an African population