Tropical Journal of Pathology and Microbiology

Histopathological study of placenta in association with deranged thyroid profile,in known case of pre-eclampsia/eclampsia

2022-05-05T17:05:02+0530

Objectives: To assess the histo-morphology of placenta in association with abnormal thyroid hormone levels in patients with Pre-eclampsia/Eclampsia, in relation to the birth weight of the baby. Methods: The study was performed in the department of Pathology over a period of 3 months. Cases and controls were evaluated on the basis of 3rd trimester TSH level of the Antenatal patients. Cases were considered as patients who had levels of TSH outside the normal range in 3rdtrimester(0.3-3.1mIU/L).Out of 50 patients ,15 cases and 33 controls were defined. Histopathological report of the resected placenta specimens was received. Clinical details of mother and birth weight of baby were collected. Finally, the correlation between placental histo-morphology, mother's diagnosis and baby birth weight were correlated. Results: Among all the cases, 9 patients (60%) were diagnosed with pre-eclampsia, as compared to 4 (14.8%) among controls. With respect to histology, hemorrhage in the placenta wasobserved more among the cases (13/15; 86.6%) as compared to controls (51.8%). Calcification was more among the controls (55.5% vs 26.6%). Among other characteristics like placental weight, infarction, chorangiosis, syncytial knots and villitis, no significant difference was noted. 58.8% (10/17) babies born to cases had Low birth weight (<2.5 kg) compared to 40.7% in controls. Conclusion: The occurrence of pre-eclampsia was high among the mothers with abnormal thyroid hormone levels. The similar observations were seen in the increased incidence of low birth weight babies. So, we strongly recommend to perform thyroid screening in all the ANC patients.

Clinico-Pathological Spectrum of Laryngeal Lesions Over Seven years ina Tertiary Hospital

2022-05-13T12:52:08+0530

Objectives: To study the frequency of different pathological lesions in the larynx and theirhistopathological features.

Methods: This is a seven years study conducted in the histopathologysection of the department of laboratory medicine, ACH from January 2014 to December 2020 ontissue specimens from the larynx. Light microscopy was used for making a diagnosis andimmunohistochemistry was done for confirmation of diagnosis as required.

Results: A total of 49cases were received during this period of which 36 were males and 13 were females. The ageranged from 4 years to 90 years with the highest incidence found between 31 to 40 years (12cases). The most common site of involvement was glottis (42 cases), followed by supra-glottis (4)and sub-glottis (3). The majority of lesions were benign (35), dysplasia (3), and malignant (11).There were 19 polyps, 3 nodules, 3 contact ulcers, 3 pyogenic granulomas, 2 cysts, 2 papillomatosis,1 inflammatory myofibroblastic tumor, 1 stenosis, 1 Wegener’s granulomatosis, 10 squamous cellcarcinoma and 1 lymphoma. All cases of squamous cell carcinomas involved glottis with a mean ageof 68.1 years with an M: F of 9:1. Lymphoma involved supra-glottis in a young 24-year-old male andit was B-cell non-Hodgkin lymphoma.

Conclusions: Our study revealed that laryngeal lesions havea predilection for males and predominantly involve glottis (vocal cord). The majority of lesions werebenign and non-neoplastic with polyps constituting 38.7% of all cases. Malignancies formed 22.9%of the total with squamous cell carcinoma making up 90.9% of all malignant cases.

Unravelling the mystery behind an unusual case of Portal Hypertension

2022-05-13T13:01:00+0530

A 38yr old male was incidentally detected to have chronic liver disease with portal hypertension. Hegives a family history of liver disease. On complete workup, the arsenic levels in his family memberswere found to be high. His liver biopsy showed features of Hepatoportal sclerosis. Two years later,his liver imaging showed a suspicious nodule in the Right lobe, following which he underwent a livedonor liver transplant. Histopathology of the explanted liver revealed, areas of cavernoushemangioma, epithelioid hemangioendothelioma with a focus of diffusely infiltrating Angiosarcoma,in a background of Hepatoportal sclerosis.