“HIDING IN THE GULLET ” - A Case Report of Neuroendocrine tumor of supraglottic Larynx with brief Literature Review.
Keywords:
Larynx, neuroendocrine tumor, well differentiated
Abstract
Laryngeal neuroendocrine tumors(NET) are infrequent tumors of the head and neck comprising <1% of all laryngeal neoplasms1. These tumors are common in elderly men and often occur in supraglottic larynx. They have a wide pathologic spectrum ranging from well differentiated neuroendocrine tumors(NETs) to poorly differentiated neuroendocrine carcinomas(NECs). In this case report we present the occurrence of a grade II Neuroendocrine tumor of supraglottic larynx in a elderly female which is rarely reported in literature.
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References
1. Ferlito A, Devaney KO, Rinaldo A. Neuroendocrine neoplasms of the larynx: advances in identifcation, understanding, and management. Oral Oncol. 2006;42:770–88. [DOI] [PubMed] [Google Scholar]
2. Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classifcation framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol.
2018;31(12):1770–86. [DOI] [PMC free article] [PubMed]
3. Perez-Ordoñez B. Neuroendocrine carcinomas of the larynx and head and neck: challenges in classifcation and grading. Head Neck Pathol. 2018;12:1–8. [Google Scholar]
4. Choe J, Kim KW, Kim HJ, Kim DW, Kim KP, Hong SM et al (2019) What is new in the 2017 World Health Organization classification and 8th American Joint Committee on Cancer Staging system for pancreatic neuroendocrine neoplasms? Korean J Radiol 20:5–17
5. van der Laan TP, Plaat BEC, van der Laan BFAM, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases. Head Neck. 2015;37:707–15. [DOI] [PubMed] [Google Scholar]
6. Wenig BM, Hyams VJ, Heffner DK. Moderately differentiated neuroendocrine carcinoma of the larynx: a clinicopathologic study of 54 cases. Cancer. 1988;62:2658–2676. doi: 10.1002/1097-0142(19881215)62:12<2658::AID-CNCR2820621235>3.0.CO;2-M. [DOI] [PubMed] [Google Scholar]
7. Strosberg C, Ferlito A, Triantafyllou A, et al. Update on neuroendocrine carcinomas of the larynx. Am J Clin Pathol. 2019;152:686–700. doi: 10.1093/ajcp/aqz106. [DOI] [PubMed] [Google Scholar]
8. Kao H-L, Chang W-C, Li W-Y, Chia-Heng Li A, Fen-Yau LA. Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival, and pathogenesis. Am J Surg Pathol. 2012;36:185–192. doi: 10.1097/PAS.0b013e318236d822. [DOI] [PubMed] [Google Scholar]
9. 9. Sripodok, P., Kouketsu, A., Kuroda, K. et al. Primary Oral Mixed Neuroendocrine–Non- neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature. Head and Neck Pathol 18, 13 (2024). https://doi.org/10.1007/s12105-024-01613-w
2. Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classifcation framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol.
2018;31(12):1770–86. [DOI] [PMC free article] [PubMed]
3. Perez-Ordoñez B. Neuroendocrine carcinomas of the larynx and head and neck: challenges in classifcation and grading. Head Neck Pathol. 2018;12:1–8. [Google Scholar]
4. Choe J, Kim KW, Kim HJ, Kim DW, Kim KP, Hong SM et al (2019) What is new in the 2017 World Health Organization classification and 8th American Joint Committee on Cancer Staging system for pancreatic neuroendocrine neoplasms? Korean J Radiol 20:5–17
5. van der Laan TP, Plaat BEC, van der Laan BFAM, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases. Head Neck. 2015;37:707–15. [DOI] [PubMed] [Google Scholar]
6. Wenig BM, Hyams VJ, Heffner DK. Moderately differentiated neuroendocrine carcinoma of the larynx: a clinicopathologic study of 54 cases. Cancer. 1988;62:2658–2676. doi: 10.1002/1097-0142(19881215)62:12<2658::AID-CNCR2820621235>3.0.CO;2-M. [DOI] [PubMed] [Google Scholar]
7. Strosberg C, Ferlito A, Triantafyllou A, et al. Update on neuroendocrine carcinomas of the larynx. Am J Clin Pathol. 2019;152:686–700. doi: 10.1093/ajcp/aqz106. [DOI] [PubMed] [Google Scholar]
8. Kao H-L, Chang W-C, Li W-Y, Chia-Heng Li A, Fen-Yau LA. Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival, and pathogenesis. Am J Surg Pathol. 2012;36:185–192. doi: 10.1097/PAS.0b013e318236d822. [DOI] [PubMed] [Google Scholar]
9. 9. Sripodok, P., Kouketsu, A., Kuroda, K. et al. Primary Oral Mixed Neuroendocrine–Non- neuroendocrine Neoplasm (MiNEN): A Rare Case Report and Review of the Literature. Head and Neck Pathol 18, 13 (2024). https://doi.org/10.1007/s12105-024-01613-w
How to Cite
Deepthi A, Manaswini R, & Srijanaki M. (2025). “HIDING IN THE GULLET ” - A Case Report of Neuroendocrine tumor of supraglottic Larynx with brief Literature Review. Tropical Journal of Pathology and Microbiology, 11(1), 1-4. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/677
Section
Case Report
Copyright (c) 2025 Author (s). Published by Siddharth Health Research and Social Welfare Society
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