Hematolymphoid Malignancies with Neurological Manifestations and Hand-mirror cells in Peripheral Blood: A Report of two cases

  • Dr Sangeetha Seshagiri Karnam National Institute of Mental Health and Neurosciences, Bengaluru
Keywords: Hematolymphoid malignancies, Neurological manifestations, Hand-mirror cells


Hematolymphoid malignancies(HLM) can present with clinical features of systemic involvement and show hand-mirror cells(HMCs) in peripheral blood.

Two-patients presented with back pain and lower-limb weakness, blood smears revealed atypical cells, HMCs and thrombocytopenia. Imaging studies showed extradural spinal lesions. Histopathology of laminectomy specimens revealed myeloid sarcoma and diffuse B-cell lymphoma.

HMCs can be seen in malignant and non-malignant conditions. Presence of HMCs may be the initial finding in peripheral blood indicating underlying malignancy with or without generalized symptomatology and leucocytosis. This study aims to emphasize that presence of HMCs should prompt appropriate investigations and management after ruling out reactive conditions.


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How to Cite
Karnam, D. S. S. (2024). Hematolymphoid Malignancies with Neurological Manifestations and Hand-mirror cells in Peripheral Blood: A Report of two cases. Tropical Journal of Pathology and Microbiology, 10(1), 1-4. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/641
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