A study of E- Cadherin in benign and malignant breast lesions with its correlation with histopathology

  • Dr ravikant Verma Bava raghav das medical College gorakhpur up
  • Dr Shilpa Vahikar B R D medical college Gorakhpur UP
  • Dr Shaila Kumari Mitra B R D medical college Gorakhpur UP
  • Dr Aakanchha Dubey B R D medical college Gorakhpur UP
  • Dr Pushpendra Sagar B R D medical college Gorakhpur UP
  • Dr Kanchan shrivastava B R D medical college Gorakhpur UP
  • Dr Deval brajesh B R D medical college Gorakhpur UP
  • Dr Dharmendra Singh B R D medical college Gorakhpur UP
Keywords: E- Cadherin, Benign Breast Lesion, Malignant Breast Lesions, Histopathology



Breast diseases are showing a rising trend worldwide. A number of studies have been done to show the magnitude of problem. Various breast lesions include inflammatory lesions, benign proliferative breast diseases like firoadenosis, fibrocystic disease papillomas etc. and various cancers. Much concern is given to malignant lesions of breast. Breast cancer ranks first among malignant tumors affecting female in many part of world.

Aims And Objectives

  1. We aimed to study correlation between histopathology and immunohistochemical analysis of E- cadherin in benign and malignant breast lesions
  2. To study role of E- cadherin in differentiating benign verses malignant breast lesions

STUDY DESIGN- Cross-sectional study.

SAMPLE SIZE- The present study was conducted on 100 cases of breast tumors. The study was carried out to find out the histological type of lesion along with role of E-cadherin in benign and malignant breast lesions.

INCLUSION CRITERIA FOR HISTOPATHOLOGICAL EXAMINATION-Resected breast tissue specimens suspected to have benign and neoplastic lesions along with all the mastectomy specimen.


  • Inadequate tissue sample.
  • Autolysed tissue sample.


RESULT- Out of 100 cases studied, 22 cases were benign and 78 cases were malignant lesions.


CONCLUSION- Present study demonstrates that E-cadherin is strongly expressed in all benign breast lesions and there is increasing loss of E-cadherin expression with increasing grade/severity of malignancy.


Download data is not yet available.

Author Biographies

Dr Shilpa Vahikar, B R D medical college Gorakhpur UP


Dr Shaila Kumari Mitra, B R D medical college Gorakhpur UP



1. Boring CC, Squirs TS, Tong T, et al ; Cancer statistics. Cancer J Clin 1994: 44:7-26.
2. Kumar, Abbas, Fusto, Aster. Pathologic Basis of disease ; The Breast , Carcinoma of Breast , Chapter 23, Robbins and Cotran, 1069-1074.
3. Freddie Bray et al ,2004. Breast Cancer Res. 2004; 6(6): 229-239. Published online 2004 Aug. 26.
4. Rosai and Ackermans surgical Pathology Tenth edition Volume 2, Chapter 20, page 1682.
5. Jamal A ; R. Siegel E. L.,Warel, T. Murray, J. Xu M. Smigal and J . Thun, 2006. Cancer Statistics. CA. J.Clin; 56: 106-130.
6. Marwa Elshaer; Histopathological and IHC Study of E-cadherin in breast neoplasia. Journal of Medical Sciences , 7: 740-747.
7. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden. Globocan 2000. Int J Cancer 2001,94:153-156.
8. National cancer Registry Programme. Ten year consolidated report of the Hospital based cancer Registries, 1984-1993, an assessment of the burden and care of cancer patients. New Delhi: Indian Council of Medical Research; 2001.
9. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991;251:1451-1455.
10. Takeichi M. Morphogenetic roles of classic cadherin. CurrOpin Cell Biol. 1995;7:619-627.
11. Nelson W. Regulation of cell adhesion and development of epithelial cell surface polarity. Curr Top Membr.1994;41:123-142.
12. Gumbiner B. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell. 1996;84:345-357.
13. Bracke ME, Van Roy FM, Mareel MM. The E Cadherin/catenin complex in invasion of metastasis .Lurr Top Microbiology Immunology. 1996; 213(pt1):123-161.
14. Larue L. ohsugi M, Hirchenhain J, Kemler R.E-Cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natt Acad Sci USA 1994; 91: 8263-8267.
15. Berx G, Cleton -Jansen AM, Nollet F. et al. E-Cadherin is a tumourSupressor gene Mutated in human lobular breast Cancers EMBO J. 1995; 14: 6107-6115.
16. Rajeev Singhai, Vinayak W Patil , Sanjog R jaiswal et al . E – cadherin as a diagnostic biomarker in breast cancer ; N. Am J. med. Sci .may 2011; 3(5): 227- 233.
17. Charpin C, Garcia S. Bonnier P, et al. Reduced E -Cadherin IHC expression in LN negative Breast Ca Correlates with 10 yrs. Survival. AM j. Clin pathol 1998; 109: 431-438.
18. A.Khemka, N Chakrabarti, S Shah and V. P. Patel; palpable breast lumps: Fine Needle Aspiration Cytology versus Histopatology: a correlation of Diagnostic Accuracy. The internet Journal of Surgery 2009: 18(1)
19. Vishal G. Mudholkar et al Histopathological Study of Neoplastic lesion of Breast .Indian Medical Gazette(2012).
20. Alexander AB, Helenice G, Cesar AL, Rezende , Agostinho PG et al: A Comparis on of Aspiration Cytology and Core Needle Biopsy According to Tumar Size of Suspicious Breast Lesions . Diagnostic Cytopathology 2007:36(1).
21. Lee A.H.S., Gillett C.E., Ryder K., Fentiman I.S., Miles D.W., Millis R.R.- Different patterns of inflammation and prognosis in invasive carcinoma of the breast. Histopathology. 48: 692-701, 2006.
22. Mahua Choudhry et al 1995 Vissa Shanti et al, J Biosci Tech, Vol 2(5), 2011, 367-378.
23. ReeniMalik, V K Bhardwaj, Breast lesions in young female- a 20 year study for significance of early recognition. Indian J PatholMicrobiol 2003; Vol 46(4): 559-562.
24. Kurubasree Lakshmi 2006 Rajiv Gandhi University of Health Sciences , Karnataka, Banglore.
25. Bane, A.L., Tjan, R.K. Parkes, I. Andrulis and F.P.O Malley, 2005. Invasive lobular carcinoma: To grade or not to grade. Mod. Pathol., 18: 621-628.
26. Marwa Elshaer (2007). Histopathological and Immunohistochemical Study of E-cadherin in Breast Neoplasia. J. Med.Sci., 7(5):740-747.
27. Bukholm,I.K., J. M. Nesland and A.L. Borresen-Dale, 2000. Re-expression of E-cadherin, alpha-catenin and beta-catenin, but not of gamma-catenin, in metastatic tissue from breast cancer patients. J. Pathol; 190: 15-19.
28. Hina S.Qureshi et al (2006). E-cadherin Status in Breast Cancer Correlates With Histologic Type But Does Not Correlate With Established Prognostic Parameters. Am J Clin Pathol 2006; 125:377-385.
How to Cite
Verma, D. ravikant, Dr Shilpa Vahikar, Dr Shaila Kumari Mitra, Dr Aakanchha Dubey, Dr Pushpendra Sagar, Dr Kanchan shrivastava, Dr Deval brajesh, & Dr Dharmendra Singh. (2023). A study of E- Cadherin in benign and malignant breast lesions with its correlation with histopathology. Tropical Journal of Pathology and Microbiology, 9(2), 5-12. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/621
Original Article