Role of The Bethesda system for reporting fine needle aspiration cytology of lesions of thyroid and it’s histopathological correlation

  • ROSE MATHEW CHERKOTTU yenepoya medical college
  • Krishnaraj Upadhyaya Professor, Department of pathology
  • Shubha Sudhakar
Keywords: Cytohistologic correlation, Fine needle aspiration, thyroid lesion, Thyroid, The Bethesda system


The incidence of clinically apparent thyroid swellings in the general population is 4–5%. Majority of these swellings are benign in nature, among which goiter being most common. The prevalence of goiter is more than 40 million in India with more than 2 billion globally. The Bethesda system is a uniform reporting system for thyroid cytology that facilitates the clarity of communication among cytopathologists, radiologists, and surgeons and facilitates cytohistologic correlation for thyroid diseases. METHODS: This is a retrospective review done by retrieving the records (cytology and histopathology) of 50 patients who have undergone FNAC of thyroid from the archives of Department of Pathology over a period of 1.5 years and the results were analyzed using descriptive statistics and Chi square test with Software SPSS version 23.

RESULTS: Based on the Bethesda system of classification of thyroid lesions, out of 44 satisfactory samples; 33 lesions were diagnosed as benign (Group 2), 1 was in category of suspicious for follicular neoplasm(group 4), 2 were diagnosed as suspicious for malignancy (Group 5), and 8 cases were malignant (Group 6). In the present study, the sensitivity of FNAC was 100%, specificity 83%.

CONCLUSION: Reviewing the thyroid FNAs with the Bethesda system for reporting allowed precise cytological diagnosis. It represents standardization and reproducibility in reporting thyroid cytology with improved clinical significance and greater predictive value. Nature of the disease, experience of cytopathologist, and understanding of certain limitations determine its diagnostic utility.

Keywords: Cytohistologic correlation, Fine‑needle aspiration, thyroid lesion, Thyroid, The Bethesda system,


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Author Biographies

Krishnaraj Upadhyaya, Professor, Department of pathology

MD,Professor, Department of pathology

Shubha Sudhakar

MD, Department of pathology


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How to Cite
CHERKOTTU, R. M., Upadhyaya, K., & Sudhakar, S. (2022). Role of The Bethesda system for reporting fine needle aspiration cytology of lesions of thyroid and it’s histopathological correlation. Tropical Journal of Pathology and Microbiology, 8(5), 60-64. Retrieved from
Original Article