Evaluation of diagnostic accuracy of FNAC and correlation with histopathology in thyroid lesions
Abstract
Aim: The aim of the study is to evaluate the accuracy of FNAC diagnosis in non neoplastic & neoplastic lesions of thyroid, and correlating with histopathological findings.
Materials and Methods: This was a prospective study done in department of Pathology, Tagore medical college for a period of 3 years. 115 cases of thyroid subjected to FNAC where histopathology diagnosis was available were included in the study. The correlation of FNAC diagnosis with histopathology was made and the results were analysed.
Results: The range of the age of the patient in this study was 25 to 60 years. The male to female ratio was 18.5:81.5. The maximum cases were colloid goitre (59.2%) in which 12.5% were with features of papillary hyperplasia. Occurrences of dual pathology were seen in our study with one case of Hashimoto’s thyroiditis with focus of papillary carcinoma and the other was medullary carcinoma with papillary carcinoma. 2 cases of anaplastic thyroid carcinoma were also seen.
Conclusion: In our study sensitivity of FNAC in detecting thyroid lesions was 93.75%, and the specificity was 97.01%. FNAC of thyroid had a diagnostic accuracy of 95.65% which clearly indicates that FNAC can be used as non invasive, cost effective and a safe diagnostic method for defining thyroid disorders.
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References
2. Das KD, Khanna CM, Tripathi RP, Pant CS, Mandal AK, Chandra S,et al. Solitary nodular goiter: Review of cytomorphologic features in 441cases. Acta Cytol 1999;43(4):563-74.
3. Afroze N, Kayani N, Hasan SH. Role of fine needle aspiration cytology in the diagnosis of palpable thyroid lesions. Indian J Pathol Microbiol. 2002 Jul;45(3):241-6. [PubMed]
4. Handa U, Garg S, Mohan H, Nagarkar N. Role of fine needle aspiration cytology in diagnosis and management of thyroid lesions: A study on 434 patients. J Cytol 2008;25(1):13-7.
5. Yeung MJ, Serpell JW. Management of the solitary thyroid nodule. Oncologist. 2008 Feb;13(2):105-12. doi: 10.1634/theoncologist.2007-0212. [PubMed]
6. Esmaili HA, Taghipour H. Fine-needle aspiration in the diagnosis of thyroid diseases: An appraisal in our institution. ISRN Pathology. 2012 Sep 3;2012.
7. Kumar S, Aqil S, Dahar A. Role of fine needle aspiration cytology in thyroid diseases. J Surg Pak 2008;13(1):22-5.
8. Cap J, Ryska A, Rehorkova P, Hovorkova E, Kerekes Z, Pohnetalova D. Sensitivity and specificity of the fine needle aspiration biopsy of the thyroid: clinical point of view. Clin Endocrinol (Oxf). 1999 Oct 1;51(4):509-15. [PubMed]
9. Clary KM, Condel JL, Liu Y, Johnson DR, Grzybicki DM, Raab SS. Interobserver variability in the fine needle aspiration biopsy diagnosis of follicular lesions of the thyroid gland. Acta cytologica. 2005 Jul 1;49(4):378-82.
10. Somma J, Schlecht NF, Fink D, Khader SN, Smith RV, Cajigas A. Thyroid fine needle aspiration cytology: follicular lesions and the gray zone. Acta Cytol. 2010 Mar-Apr;54(2):123-31. [PubMed]
11. Gupta S, Sodhani P, Jain S, Kumar N. Morphologic spectrum of papillary carcinoma of the thyroid: role of cytology in identifying the variants. Acta Cytol. 2004 Nov-Dec;48(6):795-800.
12. Mundasad B, Mcallister I, Carson J, Pyper P. Accuracy of fine needle aspiration cytology in diagnosis of thyroid swellings. Internet J Endocrinol. 2006;2(2).
13. Borget I, Vielh P, Leboulleux S, Allyn M, Iacobelli S, Schlumberger M, de Pouvourville G. Assessment of the cost of fine-needle aspiration cytology as a diagnostic tool in patients with thyroid nodules. Am J Clin Pathol. 2008 May;129(5):763-71. doi: 10.1309/H86KM785Q9KBWPW5. [PubMed]
14. Bukhari MH, Niazi S, Hanif G, Qureshi SS, Munir M, Hasan M, Naeem S. An updated audit of fine needle aspiration cytology procedure of solitary thyroid nodule. Diagn Cytopathol. 2008 Feb;36(2):104-12. doi: 10.1002/dc.20731. [PubMed]
15. Stavrić GD, Karanfilski BT, Kalamaras AK, Serafimov NZ, Georgievska BS, Korubin VH. Early diagnosis and detection of clinically non-suspected thyroid neoplasia by the cytologic method: a critical review of 1536 aspiration biopsies. Cancer. 1980 Jan 15;45(2):340-4. [PubMed]
16. Kantasueb SA, Sukpan KO, Mahanupab PO. The study of thyroid lesions and the correlation between histological and cytological findings. Chiang Mai Med J 2010;49(3):105–10.
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