Evaluation of hematological parameters and hemodialysis outcomes in patients with chronic kidney disease from north Gujarat: A prospective study

  • Deepika Modi Assistant professor, Department of pathology, Banas Medical College & Research Centre, Palanpur, Gujarat, India
  • Jayesh Modi Associate Professor, Department of Uro-Surgery, Banas Medical College & Research Centre, Palanpur, Gujarat, India
  • Premaram Chaudhary Associate Professor, Department of Physiology, Banas Medical College & Research Centre, Palanpur, Gujarat, India
  • Sunita Dinkar Dinkar Professor, Department of Surgery, Banas Medical College & Research Centre, Palanpur, Gujarat, India
Keywords: hemoglobin, renal failure, post-hemodialysis, hemoglobin

Abstract

ABSTRACT

Background: As chronic kidney disease (CKD) progresses the changes in hematological parameters become more evident. The present study aimed to determine the changes in hematological parameters and to evaluate effect of hemodialysis on the levels of serum creatinine and urea in patients with CKD from north Gujarat.

Materials and methods: A prospective cross-sectional study conducted in patients with CKD who were on hemodialysis, age between 30 to 70 years, serum creatinine level more than 1.5 mg/dL. The hematological tests were carried out in 50 patients with CKD and they were compared with 50 age and sex matched controls. All hematological parameters were measured. Serum creatinine and urea were estimated before and after hemodialysis.

Results: The mean age and gender was comparable between the groups. The hemoglobin, red blood cell count, packed cell volume, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and platelets were significantly lower in CKD group compared to control group (P<0.05). However, the mean neutrophil, lymphocyte, monocyte, and eosinophil count were significantly higher in patients with CKD compared to controls (P<0.05). The mean serum creatinine was higher in CKD group and significantly reduced after hemodialysis (11.61 mg/dL vs. 5.53 mg/dL; P<0.0001). Similarly, the mean urea concentration was higher in CKD group and significantly reduced after hemodialysis (143 mg/dL vs. 38.47 mg/dL; P<0.0001).

Conclusion: Hematological parameters can be used as markers in patients with CKD and hemodialysis is an effective treatment in reducing serum creatinine and urea in patients with renal failure from north Gujarat.

Keywords: hemoglobin, renal failure, post-hemodialysis, hemoglobin

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Author Biographies

Deepika Modi, Assistant professor, Department of pathology, Banas Medical College & Research Centre, Palanpur, Gujarat, India

Background: As chronic kidney disease (CKD) progresses, changes in hematological parametersbecome more evident. Present study aimed to determine changes in hematological parameters andto evaluate effect of hemodialysis on levels of serum creatinine and urea in patients with CKD fromnorth Gujarat. Materials and methods: A prospective cross-sectional study was conducted inpatients with CKD who were on hemodialysis, aged between 30 to 70 years, serum creatinine levelof more than 1.5 mg/dL. hematological tests were carried out in 50 patients with CKD, and werecompared with same number of patients in control group which were matched (or comparable) inage and sex. All hematological parameters including Serum creatinine and urea were estimatedbefore and after hemodialysis. Results: mean age and gender were comparable between groups.Hemoglobin, red blood cell count, packed cell volume, mean cell volume, mean cell hemoglobin,mean cell hemoglobin concentration and platelets were significantly lower in CKD group compared tocontrol group (P<0.05). However, mean neutrophil, lymphocyte, monocyte, and eosinophil countwere significantly higher in patients with CKD than controls (P<0.05). mean serum creatinine wasmore elevated in CKD group and reduced considerably after hemodialysis (11.61 mg/dL vs 5.53mg/dL; P<0.0001). Similarly, mean urea concentration was higher in CKD group and significantlyreduced after hemodialysis (143 mg/dL vs 38.47 mg/dL; P<0.0001). Conclusion: Hematologicalparameters can be used as markers in patients with CKD, and hemodialysis is an effective treatmentin reducing serum creatinine and urea in patients with renal failure from north Gujarat.

Jayesh Modi, Associate Professor, Department of Uro-Surgery, Banas Medical College & Research Centre, Palanpur, Gujarat, India

Background: As chronic kidney disease (CKD) progresses, changes in hematological parametersbecome more evident. Present study aimed to determine changes in hematological parameters andto evaluate effect of hemodialysis on levels of serum creatinine and urea in patients with CKD fromnorth Gujarat. Materials and methods: A prospective cross-sectional study was conducted inpatients with CKD who were on hemodialysis, aged between 30 to 70 years, serum creatinine levelof more than 1.5 mg/dL. hematological tests were carried out in 50 patients with CKD, and werecompared with same number of patients in control group which were matched (or comparable) inage and sex. All hematological parameters including Serum creatinine and urea were estimatedbefore and after hemodialysis. Results: mean age and gender were comparable between groups.Hemoglobin, red blood cell count, packed cell volume, mean cell volume, mean cell hemoglobin,mean cell hemoglobin concentration and platelets were significantly lower in CKD group compared tocontrol group (P<0.05). However, mean neutrophil, lymphocyte, monocyte, and eosinophil countwere significantly higher in patients with CKD than controls (P<0.05). mean serum creatinine wasmore elevated in CKD group and reduced considerably after hemodialysis (11.61 mg/dL vs 5.53mg/dL; P<0.0001). Similarly, mean urea concentration was higher in CKD group and significantlyreduced after hemodialysis (143 mg/dL vs 38.47 mg/dL; P<0.0001). Conclusion: Hematologicalparameters can be used as markers in patients with CKD, and hemodialysis is an effective treatmentin reducing serum creatinine and urea in patients with renal failure from north Gujarat.Keywords: Hemoglobin, Renal failure, Post-hemodialysis, HemoglobinCorresponding AuthorHow to Cite this ArticleTo BrowseJayesh Modi, Associate Professor, Department of Uro-Surgery, Banas Medical College & Research Centre,Palanpur, Gujarat, India.Email: Deepika Modi, Jayesh Modi, Premaram Chaudhary,Sunita Dinkar, Evaluation of hematologicalparameters and hemodialysis outcomes in patientswith chronic kidney disease from north Gujarat: Aprospective study. Trop J Pathol Microbiol.2021;7(5):266-271.Available Fromhttps://pathology.medresearch.in/index.php/jopm/article/view/555Manuscript ReceivedReview Round 1Review Round 2Review Round 3Accepted2021-09-012021-09-022021-09-092021-09-162021-09-23Conflict of InterestFundingEthical ApprovalPlagiarism X-checkerNoteNilNilYes19%© 2021by Deepika Modi, Jayesh Modi, Premaram Chaudhary, Sunita Dinkarand Published by Siddharth Health Research andSocial Welfare Society. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International Licensehttps://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].Tropical Journal of Pathology and Microbiology2021;7(5)266

Premaram Chaudhary, Associate Professor, Department of Physiology, Banas Medical College & Research Centre, Palanpur, Gujarat, India

Background: As chronic kidney disease (CKD) progresses, changes in hematological parametersbecome more evident. Present study aimed to determine changes in hematological parameters andto evaluate effect of hemodialysis on levels of serum creatinine and urea in patients with CKD fromnorth Gujarat. Materials and methods: A prospective cross-sectional study was conducted inpatients with CKD who were on hemodialysis, aged between 30 to 70 years, serum creatinine levelof more than 1.5 mg/dL. hematological tests were carried out in 50 patients with CKD, and werecompared with same number of patients in control group which were matched (or comparable) inage and sex. All hematological parameters including Serum creatinine and urea were estimatedbefore and after hemodialysis. Results: mean age and gender were comparable between groups.Hemoglobin, red blood cell count, packed cell volume, mean cell volume, mean cell hemoglobin,mean cell hemoglobin concentration and platelets were significantly lower in CKD group compared tocontrol group (P<0.05). However, mean neutrophil, lymphocyte, monocyte, and eosinophil countwere significantly higher in patients with CKD than controls (P<0.05). mean serum creatinine wasmore elevated in CKD group and reduced considerably after hemodialysis (11.61 mg/dL vs 5.53mg/dL; P<0.0001). Similarly, mean urea concentration was higher in CKD group and significantlyreduced after hemodialysis (143 mg/dL vs 38.47 mg/dL; P<0.0001). Conclusion: Hematologicalparameters can be used as markers in patients with CKD, and hemodialysis is an effective treatmentin reducing serum creatinine and urea in patients with renal failure from north Gujarat.

Sunita Dinkar Dinkar, Professor, Department of Surgery, Banas Medical College & Research Centre, Palanpur, Gujarat, India

Background: As chronic kidney disease (CKD) progresses, changes in hematological parametersbecome more evident. Present study aimed to determine changes in hematological parameters andto evaluate effect of hemodialysis on levels of serum creatinine and urea in patients with CKD fromnorth Gujarat. Materials and methods: A prospective cross-sectional study was conducted inpatients with CKD who were on hemodialysis, aged between 30 to 70 years, serum creatinine levelof more than 1.5 mg/dL. hematological tests were carried out in 50 patients with CKD, and werecompared with same number of patients in control group which were matched (or comparable) inage and sex. All hematological parameters including Serum creatinine and urea were estimatedbefore and after hemodialysis. Results: mean age and gender were comparable between groups.Hemoglobin, red blood cell count, packed cell volume, mean cell volume, mean cell hemoglobin,mean cell hemoglobin concentration and platelets were significantly lower in CKD group compared tocontrol group (P<0.05). However, mean neutrophil, lymphocyte, monocyte, and eosinophil countwere significantly higher in patients with CKD than controls (P<0.05). mean serum creatinine wasmore elevated in CKD group and reduced considerably after hemodialysis (11.61 mg/dL vs 5.53mg/dL; P<0.0001). Similarly, mean urea concentration was higher in CKD group and significantlyreduced after hemodialysis (143 mg/dL vs 38.47 mg/dL; P<0.0001). Conclusion: Hematologicalparameters can be used as markers in patients with CKD, and hemodialysis is an effective treatmentin reducing serum creatinine and urea in patients with renal failure from north Gujarat.

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How to Cite
Deepika Modi, Jayesh Modi, Premaram Chaudhary, & Dinkar, S. D. (2021). Evaluation of hematological parameters and hemodialysis outcomes in patients with chronic kidney disease from north Gujarat: A prospective study . Tropical Journal of Pathology and Microbiology, 7(5), 266-271. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/555
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Vol 7 No 5 (2021): Sep-Oct
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