Histopathological spectrum of premalignant and malignant endometrial lesions.

  • Farhat Abbas Senior Resident, Pathology Division, GMC Srinagar, Srinagar, Jammu and Kashmir, India
  • Farzana manzoor Senior Resident, Pathology Division, GMC Srinagar, Srinagar, Jammu and Kashmir, India
  • Rahat Abas Post graduate, Obstetrics and Gynaecology, SKIMS Medical College Srinagar, Srinagar, Jammu and Kashmir, India
  • Summyia Farooq Lecturer, Pathology Division, GMC Srinagar, Srinagar, Jammu and Kashmir, India
  • sabiha ashraf Lecturer, Pathology Division, GMC Srinagar, Srinagar, Jammu and Kashmir, India
  • Muzamil Latief Senior Resident, Nephrology, GMC Srinagar, Srinagar, Jammu and Kashmir, India
Keywords: 1 Endometrial hyperplasia, 2 Endometroid carcinoma 3 post menopausal


Introduction: The incidence of premalignant and malignant endometrial disorders increases during the postmenopausal period and these disorders are one of the common gynecological malignancies. Early diagnosis of endometrial cancers with aggressive behavior and usually in pre-malignant stages may allow simpler treatment options and also decrease the treatment-associated morbidity risk.

Objectives: To study histopathology premalignant and malignant endometrial lesions.

Materials and methods

It was a retro-prospective study that included 80 cases of endometrial hyperplasia and endometrial malignancies. The study was carried out from January 2018 to December 2019. The specimens were received as endometrial curettage, endometrial biopsy, and hysterectomy specimens. All specimens were fixed in 10% formalin. After a detailed gross examination, paraffin blocks of tissue were made; sections were cut and stained with hematoxylin and eosin. The sections were then studied under a microscope to categorize them into premalignant and malignant lesions.

Results: Most patients were in the postmenopausal women age group of 41-60 were affected. Benign endometrial hyperplasia was seen in38(47.5%) atypical hyperplasia 14(17.50%), endometroid adenocarcinoma 23(28.75%), MMMT3(3.75%), endometrial stromal sarcoma in2(2.5%)s.

Conclusion: The present study showed that endometrioid adenocarcinomas are the most common malignancies of the endometrium and are more common in postmenopausal women.


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1. Vinay Kumar, Abul K. Abbas, Jon C. Aster. Robbins & Cotran Pathologic Basis of Disease, Elsevier Philadelphia, 9th Edition, 2015.
2. Stacey E. Mills. Sternberg`s Diagnostic Surgical Pathology, wolters Kluwer Health, 6th Edition,2015.
3. Creasman WT, Odicino F, Maisonneuve P, Quinn MA, Beller U, Benedet JL, Heintz AP, Ngan HY, Pecorelli S (2006). Carcinoma of the corpus uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet 95 Suppl 1: S105-S143.
4. Robjert J. Kurman, Maria Luisa Carcangiu, C.Simon Herrington, Robert H. Young. WHO Classification Of Tumors Of Female Genital Tract, International Agency for Research on Cancer (IARC), Lyon, France, 4th Edition, 2014.
5. Abeler VM, Royne O, Thoresen S, Danielsen HE, Nesland JM, Kristensen GB (2009). Uterine sarcomas in Norway. A histopathological and prognostic survey of a total population from 1970 to 2000 including 419 patients. Histopathology 54: 355-364.
6. Harlow BL, Weiss NS, Lofton S (1986). The epidemiology of sarcomas of the uterus. J Natl Cancer Inst 76: 399-402.
7. Chan JK, Kawar NM, Shin JY, Osann K, Chen LM, Powell CB, Kapp DS (2008). Endometrial stromal sarcoma: a population-based analysis. Br J Cancer 99: 1210-1215.
8. Amant F, Tousseyn T, Coenegrachts L, Decloedt J, Moerman P, Debiec-Rychter M (2011). Case report of a poorly differentiated uterine tumour with t(10;17) translocation and neuroectodermal phenotype. Anticancer Res 31: 2367-2371.
9. Kurihara S, Oda Y, Ohishi Y, Iwasa A, Takahira T, Kaneki E, Kobayashi H, Wake N, Tsuneyoshi M (2008). Endometrial stromal sarcomas and related high-grade sarcomas: immunohistochemical and molecular genetic study of 31 cases. Am J Surg Pathol 32: 1228-1238.
10. Lee CH, Marino-Enriquez A, Ou W, Zhu M, Ali RH, Chiang S, Amant F, Gilks CB, van de Rijn M, Oliva E, Debiec-Rychter M, Dal Cin P, Fletcher JA, Nucci MR (2012). The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor. Am J Surg Pathol 36: 641-653.
11. Ashraf-Ganjoei T, Behtash N, Shariat M, Mosavi A. Low grade endometrial stromal sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases. World J Surg Oncol. 2006 Aug 9;4:50. .
12. 3. Sajitha K, Padma SK, Shetty KJ, Kishan Prasad HL, Permi HS, Hegde P. Study of histopathological patterns of endometrium in abnormal uterine bleeding. Chrismed J Health Res. 2014;1(2):76-81.
13. 4. Bolde SA, Pudale SS, Pandit GA, Matkari PP. Histopathological study of endometrium in cases of abnormal uterine bleeding. Int J Res Med Sci. 2017 Jan 26;2(4):1378--81.
14. 5. Vaidya S, Lakhey M, Vaidya SA, Sharma PK, Hirachand S, Lama S, et al. Histopathological pattern of abnormal uterine bleeding in endometrial biopsies. Nepal Med Coll J. 2013 Mar;15(1):74-7.
15. 6. Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan J, Panicker VK. Study of Endometrial Pathology in Abnormal Uterine Bleeding. J Obstet Gynaecol India. 2011 Aug;61(4):426-30.
16. Bhatta S, Sinha AK. Histopathological study of endometrium in abnormal uterine bleeding. J Pathol Nepal. 2012 Sep 25;2(4):297-300.
How to Cite
Abbas, F., manzoor, F., Abas, R., Farooq, S., ashraf, sabiha, & Muzamil Latief. (2021). Histopathological spectrum of premalignant and malignant endometrial lesions. Tropical Journal of Pathology and Microbiology, 7(5), 254-260. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/554
Original Article