Aberrant expression of E-cadherin in infiltrating ductal and lobular breast carcinomas and its correlation with clinicopathological parameters – A hospital-based study

  • Shruthi T Government Medical College, Nizamabad
  • Dr. Ramesh Chavan Professor, Department of Pathology, Jawaharlal Nehru Medical College, KLE University, Belagavi, Karnataka, India
  • Dr. Naresh Jaikumar Kulkarni Assistant Professor, Department of Pathology, Mahatma Gandhi Mission Medical College, Navi Mumbai, Mahatma Gandhi Mission Institute of Health Sciences, Navi Mumbai, India https://orcid.org/0000-0001-5915-9188
Keywords: Invasive Ductal Carcinoma (IDC), Invasive Lobular Carcinoma (ILC), E-cadherin, IHC, Grading of E-cadherin, Aberrant E-cadherin expression, Breast carcinoma


Introduction: Breast carcinoma is one of the commonest malignant tumours in women, leading to premature deaths and morbidity. E-cadherin is a 120kDa calcium-dependent transmembrane glycoprotein encoded by the CDH1 gene located on chromosome 16q21 and is expressed in most epithelial cells. Loss of E Cadherin expression implies cell discohesion and favours metastasis. The study aims to evaluate the expression of E-cadherin in breast carcinoma and its association with various histomorphological and clinicopathological parameters.

Materials and Methods : A total of 30 cases of breast carcinomas were studied, over two years. Histological grade and type were assessed by staining the paraffin-embedded sections with H & E. Using IHC technique, E-cadherin antigen was retrieved by Heat-Induced Epitome Retrieval method, and immunostaining was scored semiquantitatively. Cases were grouped as ‘preserved,’ when positivity was strong membranous, and occurred in more than 75% of the neoplastic epithelial cells and ‘aberrant’ in all the remaining cases. The scores were then correlated with the histopathological grade, histological type of tumour and clinicopathological parameters.

Results: E-cadherin was found to be preserved in 46.7% of all the breast carcinomas and aberrant in 51.7% of invasive ductal carcinomas (IDC) alone, while 100% of invasive lobular carcinomas showed aberrant expression. No significant correlation was found with E-cadherin grading and histological type of carcinoma, histopathological grade or involvement of deep surgical margin.

Conclusion: Differentiation between invasive ductal and invasive lobular carcinoma based on the loss of E-cadherin has to be done cautiously given its aberrant expression in ductal carcinomas as well.


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DOI: 10.17511/jopm.2021.i03.02
Published: 2021-06-20
How to Cite
T, S., Dr. Ramesh Chavan, & Dr. Naresh Jaikumar Kulkarni. (2021). Aberrant expression of E-cadherin in infiltrating ductal and lobular breast carcinomas and its correlation with clinicopathological parameters – A hospital-based study. Tropical Journal of Pathology and Microbiology, 7(3), 99-109. https://doi.org/10.17511/jopm.2021.i03.02
Original Article