Histopathological study of thyroid lesions in a tertiary care center in coastal belt of South India
Abstract
Introduction: Significant information regarding the lesions of thyroid can be obtained by histopatholological examination of the thyroidectomy specimens. Hence a scrupulous and methodical examination of the thyroidectomy specimens is needed. The aim of present study is to determine the prevalence of thyroid lesions in thyroidectomy specimens.
Method: About 240 thyroidectomy specimens received in the pathology department between February 2010 to January 2016 were included in the study. The lesions were basically classified into non- neoplastic and neoplastic. Percentages and simple frequency tables were used for data analysis.
Result: Out of the 240 thyroidectomy specimens 214 (89.2%) were from females and 26 (10.8%) were from males. The female: male ratio was 8.2:1. The age of the patients ranged from 2 to 83 years with a mean age of 44.6 years. 160 cases (66.7%) cases were non-neoplastic and 80 cases (33.3%) cases were neoplastic. The common non-neoplastic lesions were colloid goiter (101 cases; 42.1%) and Nodular Hashimoto thyroiditis (28 cases;11.7%). There were 22 benign tumors and 58 malignant tumors. Follicular adenoma was the most common benign tumor (18cases, 7.5%) and Papillary carcinoma was the most common malignant tumor (46 cases, 19.2%).
Conclusion: Neoplastic and non- neoplastic disorders affect thyroid gland. Most of the lesions are non- neoplastic. Colloid goiter was the most common non- neoplastic lesion. The most common benign tumor was Follicular adenoma and the most common malignant tumor was papillary carcinoma. This study differs from other studies by an increased incidence of Nodular Hashimoto thyroiditis.
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References
2. Anirban Mitra. Thyroid, In: Robbins Pathologic Basis of Disease. Cotran RS, Kumar V, Collins T editors. 8th ed. Philadelphia. WB Saunders Co; 2010.1107-26.
3. Faquin WC. The thyroid gland: recurring problems in histologic and cytologic evaluation. Arch Pathol Lab Med. 2008 Apr;132(4):622-32. doi: 10.1043/1543-2165(2008)132[622:TTGRPI]2.0.CO;2. [PubMed]
4. Kochupillai N. Clinical endocrinology in India. Curr Sci 2000;79:1061-7.
5. Unnikrishnan AG, Menon UV. Thyroid disorders in India: An epidemiological perspective. Indian Journal of Endocrinology and Metabolism. 2011;15(2):78-81.
6. Park K. Iodine deficiency disorders. In: Park's text book of Preventive and Social Medicine. 19th ed. Jabalpur. Banarsidas Bhanot. 2007. 510-11.
7. Tsegaye B, Ergete W. Histopathologic pattern of thyroid disease. East Afr Med J. 2003 Oct;80(10):525-8. [PubMed]
8. Lamfon HA. Thyroid Disorders in Makkah, Saudi Arabia. Ozean J Appl Sci 2008;1:55-8.
9. World Health Organisation Classification of Tumours. In: DeLellis RA, Lloyd RV, Heitz P, Eng C, editors. Pathology and Genetics. Tumours of Endocrine Organs. Lyon: IARC Press; 2004. p. 50.
10. Kanapilly Francis Magdalene, Narayanan O.Navya. Cribriform-Morular Variant of a Papillary Carcinoma: A Case Report Middle East Journal of Cancer 2016; 7(4): 209-213.
11. Narayanan O. Navya, Kanapilly F. Magdalene, Gopinath P. Satheesh. Synchronous Hurthle Cell Carcinoma and Papillary Carcinoma in a Patient with Hashimoto’s Thyroiditis : A Rare Case Report. Middle East Journal of Cancer 2014; 5(4): 221-224.
12. Albasri A, Sawaf Z, Hussainy AS, Alhujaily A. Histopathological patterns of thyroid disease in Al-Madinah region of Saudi Arabia. Asian Pac J Cancer Prev. 2014;15(14):5565-70.
13. Ijomone EA, Duduyemi BM, Udoye E, Nwosu SO. Histopathological review of thyroid diseases in southern Nigeria-a ten year retrospective study . Journal of Medicine and Medical Sciences 2014; 5(6) pp. 127-132.
14. Raphael Solomon, Yawale Iliyasu, AZ Mohammed. Histopathological pattern of thyroid lesions in Kano, Nigeria: A 10-year retrospective review (2002-2011). Niger J Basic Clin Sci 2015;12:55-60.
15. Champa Sushel, Tariq Wahab Khanzada, Imrana Zulfikar, Abdul Samad. Histopathological pattern of diagnoses in patients undergoing thyroid operations RMJ. 2009; 34(1): 14-16.
16. Ashwini Kolur, Anitha B, Letha P, Trupti Joshi, Jayasree, Samith Ahmed, Harish Naik. Pattern of thyroid disorder in thyroidectomy specimen. International Journal of Medical Science and Public Health. 2014; 12( 3):1446-1448.
17. Indhuja Bharathidhasan, Mangala Goneppanavar, Rajendra Singh Dhaka. Changing trends in the incidence of thyroid lesions in coastal regions of South India. International Journal of Health Sciences & Research 2015.5(6):134-140.
18. Ahmed Z, Chaudhary R, Umaru N. Study of prevalence of thyroid lesions in coastal region of Karnataka . Journal of Evolution of Medical and Dental Sciences 2013; 2(36):6995-7002.
19. Narayanappa Shiroorkar Pradeepkumar, Reecha Singh, Noyal Mariya Joseph Emerging trends in thyroid diseases in tsunami hit coastal areas of Puducherry and Cuddalore, India. Journal of Evolution of Medical and Dental Sciences 2012; 1(5): 857-863.
20. Subhabrata Sengupta, Isha Preet Tuli, Binayak Baruah, Santosh Prasad Kesari, Bhargav Ilapakurty, Amlan Gupta. Spectrum of goitrous lesions in patients at a tertiary care center of Sikkim. Sahel Medical Journal 2014;17( 3): 112-116.
21. Zois C, Stavrou I, Kalogera C, Svarna E, Dimoliatis I, Seferiadis K, et al. High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece. Thyroid 2003;13:485–9.
22. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, Grimley Evans J, Hasan DM, Rodgers H, Tunbridge F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995 Jul;43(1):55-68.
23. Jayaram G, Marwaha RK, Gupta RK, Sharma SK. Cytomorphologic aspects of thyroiditis. A study of 51 cases with functional, immunologic and ultrasonographic data. Acta Cytol. 1987 Nov-Dec;31(6):687-93.
24. Li Y, Teng D, Shan Z, Teng X, Guan H, Yu X, Fan C, Chong W, Yang F, Dai H, Gu X, Yu Y, Mao J, Zhao D, Li J, Chen Y, Yang R, Li C, Teng W. Antithyroperoxidase and antithyroglobulin antibodies in a five-year follow-up survey of populations with different iodine intakes. J Clin Endocrinol Metab. 2008 May;93(5):1751-7. doi: 10.1210/jc.2007-2368. Epub 2008 Feb 12.
25. Papanastasiou L, Vatalas IA, Koutras DA, Mastorakos G. Thyroid autoimmunity in the current iodine environment. Thyroid. 2007 Aug;17(8):729-39. [PubMed]