Squamous cell carcinoma of the renal pelvis with an associated double ureters-rare case report
Squamous cell carcinoma is rare in the renal pelvis and kidney than in the lower urinary tract. Mostly it is associated with renal stone. Here a case report of a 72-year-old male who presented with renal mass was reported. Radical nephrectomy was done, shows a tumor involves the middle pole and extends into the renal pelvis. The hilar surface shows the presence of double ureters. Histopathological examination showed a well-differentiated squamous cell carcinoma in the renal pelvis and one of the ureter. Tumor involves more than 50% of the renal parenchyma. There is also squamous metaplasia of lining epithelium of smaller length ureter seen. No evidence of urothelial dysplasia noted in the renal pelvis and both the ureters. Adjacent renal parenchyma, glomeruli show focal segmental glomerulosclerosis with mild Interstitial fibrosis and tubular atrophy(IFTA). Medium size vessels show intimal thickening and mucoid change. The final diagnosis of squamous cell carcinoma of the renal pelvis and smaller ureter infiltrating renal parenchyma, possibly secondary to the risk factor of the double ureter.
Mills, S., Hornick, J., Longacre, T., Greenson, J. and Reuter, V. Sternberg's diagnostic surgical pathology. 6th ed. Philadelphia PA: Wolters Kluwer. 2015.
Jain A, Mittal D, Jindal A, Solanki R, Khatri S, Parikh A, et al. Incidentally detected squamous cell carcinoma of renal pelvis in patients with staghorn calculi: case series with sa review of the literature. ISRN Oncol. 2011;2011:620574. doi: https://doi.org/10.5402/2011/620574.
Talwar N, Dargan P, Arora MP, Sharma A, Sen AK. Primary squamous cell carcinoma of the renal pelvis masquerading as pyonephrosis: a case report. Indian J PatholMicrobiol. 2006;49(3):418‐420.
Jiang P, Wang C, Chen S, Li J, Xiang J, Xie L. Primary renal squamous cell carcinoma mimicking the renal cyst: a case report and review of the recent literature. BMC Urol. 2015;15:69. doi: https://doi.org/10.1186/s12894-015-0064-z.
Somani BK, Nabi G, Thorpe P, Hussey J, Cook J. Is percutaneous drainage the new gold standard in the management of emphysematous pyelonephritis? Evidence from a systematic review. J Urol. 2008;179(5):1844‐1849. doi: https://doi.org/10.1016/j.juro.2008.01.019.
Bandyopadhyay R, Biswas S, Nag D, Ghosh AK. Squamous cell carcinoma of the renal pelvis presenting as hydronephrosis. J Cancer Res Ther. 2010;6(4):537‐539. doi: https://doi.org/10.4103/0973-1482.77060.
Nachiappan M, Litake MM, Paravatraj VG, Sharma N, Narasimhan A. Squamous Cell Carcinoma of the Renal Pelvis, A Rare Site for a Commonly Known Malignancy. J ClinDiagn Res. 2016;10(1):PD04‐PD6. doi: https://doi.org/10.7860/JCDR/2016/17846.7081.
Hippargi SB, Nerune SM, Kumar M. Urothelial and Squamous Cell Carcinoma of Renal Pelvis - A Rare Case Report. J ClinDiagn Res. 2016;10(9):ED19‐ED20. doi: https://doi.org/10.7860/JCDR/2016/20860.8576.
Bhaijee F. Squamous cell carcinoma of the renal pelvis. Ann DiagnPathol. 2012;16(2):124‐127. doi: https://doi.org/10.1016/j.anndiagpath.2011.08.009
Chen KS, Chuang CK, Wu CH, Liaw CC, Lee N. Upper urinary tract tumor in a duplicated collecting system: report of three cases and review of the literature. Chang Gung Med J. 2003;26(5):377‐382.
Mardi K, Kaushal V, Sharma V. Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. J Cancer Res Ther. 2010;6(3):339‐341. doi: https://doi.org/10.4103/0973-1482.73351.
Ghosh P, Saha K. Primary intraparenchymal squamous cell carcinoma of the kidney: a rare and unique entity. Case Rep Pathol. 2014;2014:256813. doi: https://doi.org/10.1155/2014/256813
Bernardini S, Adessi GL, Billerey C, Chezy E, Carbillet JP, Bittard H. Immunohistochemical detection of p53 protein overexpression versus gene sequencing in urinary bladder carcinomas. J Urol. 1999;162(4):1496‐1501.
Salehipour M, Dastgheib N, Hosseinzadeh M, Makarem A, Rezvani A, Sanati A, et al. Primary renal pelvis and ureter squamous cell carcinoma (SCC): a rare case report and review of literature. Int Med Case Rep J. 2019;12:189‐192. doi: https://doi.org/10.2147/IMCRJ.S203283.
Lee TY, Ko SF, Wan YL, Cheng YF, Yang BY, Huang DL, et al. Renal squamous cell carcinoma: CT findings and clinical significance. Abdom Imaging. 1998;23(2):203‐208. doi: https://doi.org/10.1007/s002619900324.
Raghavendran M, Rastogi A, Dubey D, Chaudhary H, Kumar A, Srivastava A, et al. Stones associated renal pelvic malignancies. Indian J Cancer. 2003;40(3):108‐112.
Imbriaco M, Iodice D, Erra P, Terlizzi A, Carlo RD, Vito CD, et al. Squamous cell carcinoma within a horseshoe kidney with associated renal stones detected by computed tomography and magnetic resonance imaging. Urol. 2011;78(1):54‐55. doi: https://doi.org/10.1016/j.urology.2010.06.006.
Tyagi N, Sharma S, Tyagi SP, Maheshwari V, Nath P, Ashraf SM, et al. A histomorphologic and ultrastructural study of the malignant tumours of the renal pelvis. J Postgrad Med. 1993;39(4):197‐201.
Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj GV, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006;7(9):735‐740. doi: https://doi.org/10.1016/S1470-2045(06)70803-8.
Shirasaki Y, Tsushima T, Nasu Y, Kumon H. Long-term consequence of renal function following nephrectomy for renal cell cancer. Int J Urol. 2004;11(9):704‐708. doi: https://doi.org/10.1111/j.1442-2042.2004.00879.x.
Bijol V, Mendez GP, Hurwitz S, Rennke HG, Nosé V. Evaluation of the nonneoplastic pathology in tumor nephrectomy specimens: predicting the risk of progressive renal failure. Am J SurgPathol. 2006;30(5):575‐584. doi: https://doi.org/10.1097/01.pas.0000194296.74097.87.
Holmäng S, Lele SM, Johansson SL. Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome. J Urol. 2007;178(1):51‐56. doi: https://doi.org/10.1016/j.juro.2007.03.033.
Nativ O, Reiman HM, Lieber MM, Zincke H. Treatment of primary squamous cell carcinoma of the upper urinary tract. Cancer. 1991;68(12):2575‐2578. doi: https://doi.org/10.1002/1097-0142(19911215)68:12<2575::aid-cncr2820681208>3.0.co;2-v.
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