Leiomyosarcoma of the tongue: A case report

  • Adwaita Gahlot Department of Pathology, Vardhman Mahavir Medical College, New Delhi, India
  • Sufian Zaheer Department of Pathology, Vardhman Mahavir Medical College, New Delhi, India
Keywords: Tongue, leiomyosarcoma, SMA


Leiomyosarcoma (LMS) of the tongue is an extremely rare malignant mesenchymal tumor. Visceral lesions are the most common and account for about 7% of all soft-tissue sarcomas. The lesion is rare in the head and neck, making up 3%–10% of all leiomyosarcomas. Primary leiomyosarcoma of the tongue is extremely rare leiomyosarcomas andrepresents 5–6% of all soft tissue sarcomas and usually, they arise in the uterus, gastrointestinal tract, and retroperitoneum. The most common sites of head and neck regions are the oral cavity (22%), the sinonasal tract (19%), and the facial skin-subcutis (17%). Smooth muscle tumors in the oral cavity usually arise from the buccal mucosa, the gingiva, and the oral floor,but only a few numbers of cases arise in the tongue.The present case shows the tumor cells arranged in fascicles and interlacing bundles. The nuclei of individual tumor cells are elongated and hyperchromatic with a moderate amount of eosinophilic cytoplasm. The tumor cells were strongly positive for immunoreactivity with Vimentin, and SMA. However, CK, P63, EMA, desmin, CD99, and S100 were negativefrom these immunohistochemical results, the pathological diagnosis was leiomyosarcoma at the tip of the tongue.The tumor cells were strongly positive vimentin and SMA. However, CK, P63, EMA, desmin, S100, and CD99 were negative. From these immunohistochemical results, the pathological diagnosis was leiomyosarcoma, left side of the tongue.


Download data is not yet available.


Ishikawa I, Enjouji M. Leiomyosarcoma cutaneous andsubcutaneous type.Areasof soft tissue tumors. Tokyo: Bunkodo;1989;134-142.

Barnes, L, Enjouji, M. Tumor and tumor-like lesions of the soft tissues. Surgical pathology of the head and neck, New York. 1985;2(6):814-821.

Azevedo RS, Pires FR, Gouvêa AF, Lopes MA, Jorge J. Leiomyosarcomas of the oral cavity: Report of a radiation-associated and a metastatic case. Oral Maxillofac Surg. 2012;16(2):227-232. doi: https://doi.org/10.1007/s10006-011-0294-5.

Schenberg ME, Slootweg PJ, Koole R. Leiomyosarcomas of the oral cavity. Report of four cases and review of the literature. J Craniomaxillofac Surg 1993;21(8):342-347. doi: https://doi.org/10.1016/s1010-5182(05)80495-0.

Mendenhall W, Mendenhall C, Werning J, Riggs C, Mendenhall N. Adult head and neck soft tissue sarcomas. Head & Neck. 2005;27(10):916-922. doi: https://doi.org/10.1002/hed.20249.

Stout AP. Leiomyoma of the oral cavity. Am J Cancer. 1938;34(9):31.

Enzinger FM, Weiss SW, Chapter 19 leioyosarcoma. Soft tissue tumors. Missouri: Mosby;1995:491-510.

Hadju SI. Pathology of soft tissue tumors. Philadelphia, PA: Lea and Febiger; 1979:311.

Muzio LL, Favia G, Mignogna MD, Piattelli A, Maiorano E. Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature. Oral Oncol. 2000;36(6):519-524. doi: https://doi.org/10.1016/s1368-8375(00)00044-0.

Wollenberg B, Muller-Hocker J, Wustrow TP. Leiomyosarcoma of the tongue. Laryngorhinootologie 1993;72:342-345.

Mayall F, Hickman J, Bulman C, Blewitt R. Leiomyosarcoma of the tongue: a very rare tumor. J Laryngol Otol. 1994;108(7):617-618. doi: https://doi.org/10.1017/s0022215100127616.

Aydin H, Dreyer T. Leiomyosarcoma of base of the tongue treated with radiotherapy: a case report. Eur J Cancer B Oral Oncol. 1994;30(B):351-355. doi: https://doi.org/10.1016/0964-1955(94)90038-8.

DOI: 10.17511/jopm.2020.i03.08
Published: 2020-03-31
How to Cite
Kapur, A. K., & Zaheer, S. (2020). Leiomyosarcoma of the tongue: A case report. Tropical Journal of Pathology and Microbiology, 6(3), 261-264. https://doi.org/10.17511/jopm.2020.i03.08
Case Report