Spectrum of histologic variants of papillary thyroid carcinoma over a period of 5 years- single institutional study
Keywords:
Papillary thyroid carcinoma, Follicular variant, Tall cell, Columnar cell, Cribriform morular, Metastasis
Abstract
Background: Thyroid carcinoma is the most common malignancy of endocrine system. They arise from two cell types present in the thyroid gland. The endodermally derived follicular cells give rise to papillary, follicular and probably anaplastic carcinomas. The neuroendocrine derived calcitonin producing C cells give rise to medullary carcinomas.
Aims and Objectives: To study the different histological variants of papillary thyroid carcinoma (PTC) in thyroidectomy specimens, their frequency, age incidence, sex distribution and presence of metastasis in the regional lymph nodes.
Materials and Methods: It was a retrospective study done in the department of Pathology over a period of 5 years from June 2014 – May 2019.
Results: A total of 98 cases of papillary thyroid carcinomas were studied out of which 71 cases were of Classic variant, 19 cases of Follicular variant, 2 cases of Papillary Microcarcinoma variant, 1 case each of Cribriform Morular variant, Warthin like variant, Tall cell variant, Columnar cell variant, Oncocytic variant and Non invasive follicular thyroid neoplasm with papillary–like nuclear features (NIFTP).
Conclusion: Classic variant of papillary carcinoma thyroid is the most common variant with the highest number of cases followed by follicular and other variants.
Downloads
Download data is not yet available.
References
1. Unnikrishnan AG, Menon UV. Thyroid disorders in India: An epidemiological perspective. Indian J Endocrinol Metab. 2011;15(2):S78-81. doi: 10.4103/2230-8210.83329
2. National Centre for Disease Informatics and Research. Trend over time for all sites and on selected sites of cancer and projection of burden of cancer. National Cancer Registry Programme. Indian Council for Medical Research 3 Year Report of Population Based Cancer Registries. Ch. 10. National Centre for Disease Informatics and Research; 2016. p. 89‑125.
3. Sonkar AA, Rajamanickam S, Singh D. Papillary thyroid carcinoma: Debate at rest. Indian J Cancer. 2010; 47(2):206‑216. doi: 10.4103/0019-509X.63025.
4. Rosai J. Albares Saavedra J. Asioli S. Fagin J.A. Franssila K. 0. Giordano T. J et al. Papillary thyroid carcinoma. In:Lloyd R. V., Osamura R. Y., Kloppel G., Rosai J. Editors: WHO Classification of Tumours of Endocrine Organs.4th edition. IARC: Lyon; 2017.p.81-91.
5. Livolsi VA, Albores-Saavedra J, Asa SL, Baloch ZW, Sobrinho-Simoes M, Wenig B, DeLellis RA, Cady B, Mazafferi EL, Hay I,Fagin JA, Weber AL, Caruso P, Voutilainen PE, Franssila KO,Williams ED, Schneider AB, Nikiforov Y, Rabes HN, Akslen L,Ezzat S, Santoro M, Eng C, Harach HR. Papillary carcinoma.In: DeLellis RA, Lloyd RV, Heitz PU, Eng C editors. WHO classification of tumours, pathology & genetics: Tumours of endocrine organs. Lyon: IARC Press; 2004. 57-66.
6. Rosai J, Tallini G. Thyroid gland. In: Rosai J editor. Rosai and Ackerman’s surgical pathology. 10th ed. New York: Mosby Elsevier 2011:487-564.
7. Nikiforov YE, Ohori NP. Papillary carcinoma. In: Nikiforov YE, Biddinger PW, Thompson LDR editors. Diagnostic pathology and molecular genetics of the thyroid: A comprehensive guide for practicing thyroid pathology. 2nd edition. Philadelphia: Wolter Kluver /Lippincott Williams &Wilkins; 2012. 183-246.
8. Boerner SL, Asa SL. Biopsy interpretation series: Biopsy interpretation of the thyroid. Epstein JI, editor. Philadelphia: Wolter Kluver /Lippincott Williams &Wilkins; 2009.
9. Al-Brahim N, Asa SL. Papillary thyroid carcinoma: An overview. Arch Pathol Lab Med 2006; 130(7):1057‑1062.
10. Rao R, Giriyan SS, Rangappa PK. Clinicopathological profile of papillary carcinoma of thyroid:A 10‑year experience in a tertiary care institute in North Karnataka, India. India. Indian J Cancer. 2017;54(3):514-518. doi: 10.4103/ijc.IJC_337_17.
11. Karkuzhali P, Yogambal M, Kumar M. An Indian Tertiary Care Hospital Scenario of Papillary Carcinoma of Thyroid. J Clinic Diag Res. 2017;11(6):EC26-EC29. doi: 10.7860/JCDR/2017/27673.10095.
12. LiVolsi VA. Papillary thyroid carcinoma: An update. Mod Pathol2011;24(2):S1-S9. doi: 10.1038/modpathol.2010.129.
13. Lindsay S. Carcinoma of the Thyroid Gland: A Clinical and Pathologic Study of 293 Patients at the University of California Hospital. Spring eld Ill: Charles C Thomas; 1960.
14. Howitt BE, Jia Y, Sholl LM, Barletta JA. Molecular alterations in partially- encapsulated or well-circumscribed follicular variant of papillary thyroid carcinoma. Thyroid. 2013;23(10):1256-1262. doi: 10.1089/thy.2013.0018. Epub 2013 Jul 17.
15. Hazard JB. Small papillary carcinoma of the thyroid. A study with special reference to so-called no encapsulated sclerosing tumor. Lab Invest. 1960;9:86-97.
16. Rosai J. Rosai and Ackerman's surgical pathology e-book. Elsevier Health Sciences; 10th edition. New york: Mosby Elsevier; 2011 Jun 20.p. 487-564.
17. Tomoda C, Miyauchi A, Uruno T, et al. Cribriform-morular variant of papillary thyroid carcinoma: clue to early detection of familial adenomatous polyposis-associated colon cancer. World J Surg. 2004;28(9):886-889. doi: https://doi.org/10.1007/s00268-004-7475-4.
18. Xu B, Yoshimoto K, Miyauchi A, Kuma S, Mizusawa N, Hirokawa M, et al. Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the beta-catenin gene. J Pathol. 2003;199(1):58-67. doi: https://doi.org/10.1002/path.1225.
19. Harach HR, Williams GT, Williams ED. Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathol. 1994;25(6):549-561. doi: https://doi.org/10.1111/j.1365-2559.1994.tb01374.x.
20. LiVolsi VA. Papillary carcinoma tall cell variant (TCV): a review. Endocr Pathol. 2010;21(1):12-15. doi: 10.1007/s12022-010-9106-y.
21. Ozaki O, Ito K, Mimura T, Sugino K, Hosoda Y. Papillary carcinoma of the thyroid. Tall-cell variant with extensive lymphocyte in ltration. Am J Surg Pathol. 1996;20(6):695-698.
22. Evans HL. Columnar-cell carcinoma of the thyroid. A report of two cases of an aggressive variant of thyroid carcinoma. Am J Clin Pathol. 1986;85(1):77-80. doi: https://doi.org/10.1093/ajcp/85.1.77.
23. Gaertner EM, Davidson M, Wenig BM. The columnar cell variant of thyroid papillary carcinoma. Case report and discussion of an unusually aggressive thyroid papillary carcinoma. Am J Surg Pathol. 1995;19(8):940-947.
24. Sobrinho-Simoes M, Nesland JM, Johannessen JV. Columnar-cell carcinoma. Another variant of poorly differentiated carcinoma of the thyroid. Am J Clin Pathol. 1988;89(2):264-267. doi: https://doi.org/10.1093/ajcp/89.2.264.
25. Wenig BM, Thompson LD, Adair CF, Shmookler B, Heffess CS. Thyroid papillary carcinoma of columnar cell type: a clinicopathologic study of 16 cases. Cancer. 1998;82(4):740-753.
26. Chen JH, Faquin WC, Lloyd RV, Nose V. Columnar cell variant of papillary thyroid carcinoma: a clinicopathologic, molecular and immunophenotypic study of nine cases with a review of the literature. Mod Pathol. 2011;24(5):739-749. doi: 10.1038/modpathol.2011.2. Epub 2011 Feb 25.
27. Evans HL. Encapsulated columnar-cell neoplasms of the thyroid. A report of four cases suggesting a favorable prognosis. Am J Surg Pathol. 1996;20(10):1205-1211.
2. National Centre for Disease Informatics and Research. Trend over time for all sites and on selected sites of cancer and projection of burden of cancer. National Cancer Registry Programme. Indian Council for Medical Research 3 Year Report of Population Based Cancer Registries. Ch. 10. National Centre for Disease Informatics and Research; 2016. p. 89‑125.
3. Sonkar AA, Rajamanickam S, Singh D. Papillary thyroid carcinoma: Debate at rest. Indian J Cancer. 2010; 47(2):206‑216. doi: 10.4103/0019-509X.63025.
4. Rosai J. Albares Saavedra J. Asioli S. Fagin J.A. Franssila K. 0. Giordano T. J et al. Papillary thyroid carcinoma. In:Lloyd R. V., Osamura R. Y., Kloppel G., Rosai J. Editors: WHO Classification of Tumours of Endocrine Organs.4th edition. IARC: Lyon; 2017.p.81-91.
5. Livolsi VA, Albores-Saavedra J, Asa SL, Baloch ZW, Sobrinho-Simoes M, Wenig B, DeLellis RA, Cady B, Mazafferi EL, Hay I,Fagin JA, Weber AL, Caruso P, Voutilainen PE, Franssila KO,Williams ED, Schneider AB, Nikiforov Y, Rabes HN, Akslen L,Ezzat S, Santoro M, Eng C, Harach HR. Papillary carcinoma.In: DeLellis RA, Lloyd RV, Heitz PU, Eng C editors. WHO classification of tumours, pathology & genetics: Tumours of endocrine organs. Lyon: IARC Press; 2004. 57-66.
6. Rosai J, Tallini G. Thyroid gland. In: Rosai J editor. Rosai and Ackerman’s surgical pathology. 10th ed. New York: Mosby Elsevier 2011:487-564.
7. Nikiforov YE, Ohori NP. Papillary carcinoma. In: Nikiforov YE, Biddinger PW, Thompson LDR editors. Diagnostic pathology and molecular genetics of the thyroid: A comprehensive guide for practicing thyroid pathology. 2nd edition. Philadelphia: Wolter Kluver /Lippincott Williams &Wilkins; 2012. 183-246.
8. Boerner SL, Asa SL. Biopsy interpretation series: Biopsy interpretation of the thyroid. Epstein JI, editor. Philadelphia: Wolter Kluver /Lippincott Williams &Wilkins; 2009.
9. Al-Brahim N, Asa SL. Papillary thyroid carcinoma: An overview. Arch Pathol Lab Med 2006; 130(7):1057‑1062.
10. Rao R, Giriyan SS, Rangappa PK. Clinicopathological profile of papillary carcinoma of thyroid:A 10‑year experience in a tertiary care institute in North Karnataka, India. India. Indian J Cancer. 2017;54(3):514-518. doi: 10.4103/ijc.IJC_337_17.
11. Karkuzhali P, Yogambal M, Kumar M. An Indian Tertiary Care Hospital Scenario of Papillary Carcinoma of Thyroid. J Clinic Diag Res. 2017;11(6):EC26-EC29. doi: 10.7860/JCDR/2017/27673.10095.
12. LiVolsi VA. Papillary thyroid carcinoma: An update. Mod Pathol2011;24(2):S1-S9. doi: 10.1038/modpathol.2010.129.
13. Lindsay S. Carcinoma of the Thyroid Gland: A Clinical and Pathologic Study of 293 Patients at the University of California Hospital. Spring eld Ill: Charles C Thomas; 1960.
14. Howitt BE, Jia Y, Sholl LM, Barletta JA. Molecular alterations in partially- encapsulated or well-circumscribed follicular variant of papillary thyroid carcinoma. Thyroid. 2013;23(10):1256-1262. doi: 10.1089/thy.2013.0018. Epub 2013 Jul 17.
15. Hazard JB. Small papillary carcinoma of the thyroid. A study with special reference to so-called no encapsulated sclerosing tumor. Lab Invest. 1960;9:86-97.
16. Rosai J. Rosai and Ackerman's surgical pathology e-book. Elsevier Health Sciences; 10th edition. New york: Mosby Elsevier; 2011 Jun 20.p. 487-564.
17. Tomoda C, Miyauchi A, Uruno T, et al. Cribriform-morular variant of papillary thyroid carcinoma: clue to early detection of familial adenomatous polyposis-associated colon cancer. World J Surg. 2004;28(9):886-889. doi: https://doi.org/10.1007/s00268-004-7475-4.
18. Xu B, Yoshimoto K, Miyauchi A, Kuma S, Mizusawa N, Hirokawa M, et al. Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the beta-catenin gene. J Pathol. 2003;199(1):58-67. doi: https://doi.org/10.1002/path.1225.
19. Harach HR, Williams GT, Williams ED. Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathol. 1994;25(6):549-561. doi: https://doi.org/10.1111/j.1365-2559.1994.tb01374.x.
20. LiVolsi VA. Papillary carcinoma tall cell variant (TCV): a review. Endocr Pathol. 2010;21(1):12-15. doi: 10.1007/s12022-010-9106-y.
21. Ozaki O, Ito K, Mimura T, Sugino K, Hosoda Y. Papillary carcinoma of the thyroid. Tall-cell variant with extensive lymphocyte in ltration. Am J Surg Pathol. 1996;20(6):695-698.
22. Evans HL. Columnar-cell carcinoma of the thyroid. A report of two cases of an aggressive variant of thyroid carcinoma. Am J Clin Pathol. 1986;85(1):77-80. doi: https://doi.org/10.1093/ajcp/85.1.77.
23. Gaertner EM, Davidson M, Wenig BM. The columnar cell variant of thyroid papillary carcinoma. Case report and discussion of an unusually aggressive thyroid papillary carcinoma. Am J Surg Pathol. 1995;19(8):940-947.
24. Sobrinho-Simoes M, Nesland JM, Johannessen JV. Columnar-cell carcinoma. Another variant of poorly differentiated carcinoma of the thyroid. Am J Clin Pathol. 1988;89(2):264-267. doi: https://doi.org/10.1093/ajcp/89.2.264.
25. Wenig BM, Thompson LD, Adair CF, Shmookler B, Heffess CS. Thyroid papillary carcinoma of columnar cell type: a clinicopathologic study of 16 cases. Cancer. 1998;82(4):740-753.
26. Chen JH, Faquin WC, Lloyd RV, Nose V. Columnar cell variant of papillary thyroid carcinoma: a clinicopathologic, molecular and immunophenotypic study of nine cases with a review of the literature. Mod Pathol. 2011;24(5):739-749. doi: 10.1038/modpathol.2011.2. Epub 2011 Feb 25.
27. Evans HL. Encapsulated columnar-cell neoplasms of the thyroid. A report of four cases suggesting a favorable prognosis. Am J Surg Pathol. 1996;20(10):1205-1211.
CITATION
DOI: 10.17511/jopm.2019.i11.16
Published: 2019-11-30
How to Cite
Uppala, P., I.V., R., Atchyuta, M., Sheik, N., B., G., & K., S. (2019). Spectrum of histologic variants of papillary thyroid carcinoma over a period of 5 years- single institutional study. Tropical Journal of Pathology and Microbiology, 5(11), 934-941. https://doi.org/10.17511/jopm.2019.i11.16
Section
Original Article
OAI - Open Archives Initiative
