Seroprevalence of HIV & HCV coinfection among patients in a rural tertiary care centre in North India
Abstract
Objective: Viral hepatitis C infection is associated with high morbidity and mortality rates. Chronic HCV infection can cause a wide spectrum of liver disease, potentially leading to severe liver damage, including cirrhosis, organ failure and hepatocellular carcinoma. It accounts for nearly 12– 32% of all cases of liver cancer and 10- 20% cases of cirrhosis of liver, both of which have high treatment costs and poor outcomes. As route of infection of Human Immunodeficiency Virus, Hepatitis B Virus (HBV) and the Hepatitis C Virus (HCV) is same, People with HIV infection are at more risk of acquiring Hepatitis B Virus (HBV) and the Hepatitis C Virus (HCV) infection. The co-infection of Hepatitis C virus with HIV accelerates disease progression and also has an effect on the management of patients infected with HIV. The prevalence of HIV co-infection with Hepatitis C virus varies widely. This study is planned to evaluate the prevalence of HIV co-infection with Hepatitis C viruses in North India.
Materials and Methods: A total of 25443 patients enrolled in the microbiology lab were retrospectively analyzed for the presence of HCV and HIV infection on the basis of the presence of anti-HCV and anti HIV markers.
Results: In patients infected with HIV, the prevalence of co-infection with HCV was 0.07%. The mean age of the study group was 28.7 years.
Discussion: The prevalence rate of HCV are increasing in patients infected with HIV. Having acquired the knowledge about the importance of such a co-infection, it is essential that all the patients infected with HIV be screened for HCV co-infection.
Downloads
References
Jain M, Chakravarti A, Verma V, Bhalla P. Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus. Indian J Pathol Microbiol. 2009;52(1):17-19.
Chung RT. Hepatitis C and B viruses: the new opportunists in HIV infection. Top HIV Med. 2006;14(2):78-83.
Kalyani CS, Lakshmi N, Lakshmi KR, Kumar VA, Cheemala SS. Seroprevalence of hepatitis B virus and hepatitis C virus co-infection in human immunodeficiency virus infected patients at a tertiary care hospital in South India. International J Res Med Sci. 2015;3(8):2041-2045. doi: http://dx.doi.org/10.18203/2320-6012.ijrms20150324
National Technical Guidelines on Antiretroviral Treatment, October2018, NACO;88.
Infographics, Global prevalence of Hiv-Hcv coinfection: 28 MARCH 2019.
HIV and AIDS in India, Available at https://www.avert.org/professionals/hiv-around-world/asia-pacific/india
Barman B, Bora K, Lynrah KG, Lyngdoh WV, Jamil M. Hepatitis C virus and its genotypes in chronic liver disease patients from Meghalaya, Northeast India. Indian J Med Microbiol. 2018;36(3):376-380. doi: http://www.ijmm.org/text.asp?2018/36/3/376/245376.
Ponamgi SP, Rahamathulla S, Kumar YN, Chandra M, Lakshmi N, Habibullah CM, et al. Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in south India and characterization of HCV genotypes. Indian J Med Microbiol. 2009;27(1):12-16.
Adewole OO, Anteyi E, Ajuwon Z, Wada I, Elegba F, Ahmed P, et al. Hepatitis B and C virus co-infection in Nigerian patients with HIV infection. J Infect Dev Ctries. 2009;3(5):369-375. doi: https://doi.org/10.3855/jidc.245.
Sungkanuparph S, Vibhagool A, Manosuthi W, Kiertiburanakul S, Atamasirikul K, Aumkhyan A, et al. Prevalence of hepatitis B virus and hepatitis C virus co-infection with human immunodeficiency virus in Thai patients: a tertiary-care-based study. J Med Assoc Thai. 2004;87(11):1349-1354.
Saravanan S, Velu V, Kumarasamy N, Nandakumar S, Murugavel KG, Balakrishnan P, et al. Coinfection of hepatitis B and hepatitis C virus in HIV-infected patients in south India. World J Gastroenterol. 2007;13(37):5015-5120. doi: 10.3748/wjg.v13.i37.5015.
Egah DZ, Banwat EB, Audu ES, Iya D, Mandong BM, Anele AA, Gomwalk NE. Hepatitis B surface antigen, hepatitis C and HIV antibodies in a low-risk blood donor group, Nigeria. East Mediterr Health J. 2007;13(4):961-966.
Mohammadi M, Talei G, Sheikhian A, Ebrahimzade F, Pournia Y, Ghasemi E, et al. Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patients. Virol J. 2009;6(1):202. doi: https://doi.org/10.1186/1743-422X-6-202.
Mahajan A, Tandon VR, Verma S, Singh JB, Sharma M. Indian J Med Microbiol. 2008;26(2):196-197. doi: http://www.ijmm.org/text.asp?2008/26/2/196/40544.
Tripathi AK, Khanna M, Gupta N, Chandra M. Low prevalence of hepatitis B virus and hepatitis C virus co-infection in patients with human immunodeficiency virus in Northern India. JAPI. 2007;55:429-431.
Tankhiwale SS, Khadase RK, Jalgoankar SV. Seroprevalence of anti-HCV and hepatitis B surface antigen in HIV infected patients. Indian J Med Microbiol. 2003;21(4):268-270.
OAI - Open Archives Initiative
