Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis coinfection in a HIV negative patient in Amritsar Punjab, India
Keywords:
Talaromyces (Penicillium) marneffei, Mycobacterium tuberculosis, co infection
Abstract
A 54-year-old, male patient with a history of Pulmonary Tuberculosis and Diabetes mellitus for the past 20 years was admitted to a tertiary care hospital with chief complaints of high-grade fever with chills, productive cough and a one month history of loss of appetite and generalized malaise. On FNAC of cervical lymph nodes; impression of tubercular pathology (AFB positive) was reported. Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis co-infection was confirmed. Talaromyces marneffei (Penicillium marneffei) is a thermally dimorphic fungus that can cause severe infections particularly in immunocompromised patients was first discovered in 1956 in the regions of Southeast Asia. It exists as mycelia form at 25 °C and yeast like form at 37 °C. A large number of T. marneffei infected patients who are HIV negative have been reported in recent years.
Downloads
Download data is not yet available.
References
1. Capponi M, Sureau P, Segretain G. Penicillosis of Rhizomys sinensis. Bulletin de la Societe de pathologie exotique. 1956;49(3):418-421.
2. Xiang Y, Guo W, Liang K. An unusual appearing skin lesion from Penicillium marneffei infection in an AIDS patient in central China. Am J Trop Med Hyg. 2015;93(1):3. doi: 10.4269/ajtmh.14-0697.
3. Segretain G. [Penicillium marneffei n.sp., agent of a mycosis of the reticuloendothelial system]. Mycopathol Mycol Appl. 1959;11:327-353. doi: 10.1007/bf02089507.
4. Chander J. Talaromycosis. In A textbook of Medical Mycology. New Delhi: Mehta Publishers;2009;506-523.
5. Wang YF, Xu HF, Han ZG, Zeng L, Liang CY, Chen XJ, et al. Serological surveillance for Penicillium marneffei infection in HIV-infected patients during 2004-2011 in Guangzhou, China. Clin Microbiol Infect. 2015;21(5):484-489. doi: 10.1016/j.cmi.2014.12.014. Epub 2014 Dec 26.
6. Wong SY, Wong KF. Penicillium marneffei Infection in AIDS. Pathol Res Int. 2011;2011. 764293. doi: 10.4061/2011/764293.
7. Duong TA. Infection due to Penicillium marneffei, an emerging pathogen: review of 155 reported cases. Clin Infect Dis. 1996;23(1):125-130. doi: https://doi.org/10.1093/clinids/23.1.125.
8. Liu GN, Huang JS, Zhong XN, Zhang JQ, Zou ZX, Yang ML, et al. Penicillium marneffei infection within an osteolytic lesion in an HIV-negative patient. Int J Infect Dis. 2014;23:1-3. doi: 10.1016/j.ijid.2013.12.019. Epub 2014 Mar 19.
9. Qiu Y, Zhang J, Liu G, Zhong X, Deng J, He Z, et al. A case of Penicillium marneffei infection involving the main tracheal structure. BMC Infect Dis. 2014;14:242. doi: 10.1186/1471-2334-14-242.
10. Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE, Sirisanthana T, Disseminated Penicillium marneffei infection in Southeast Asia. Lancet, 1994;344(8915):110-113. doi: https://doi.org/10.1016/S0140-6736(94)91287-4.
11. Ranjana KH, Priyokumar K, Singh TJ, Gupta CC, Sharmila L, Singh PN, Chakrabarti A. Disseminated Penicillium marneffei infection among HIV-infected patients in Manipur state, India. J Infect. 2002;45(4):268-271. doi: https://doi.org/10.1053/jinf.2002.1062.
12. Wu TC, Chan JWM, Ng CK, Tsang DNC, Lee MP, Li PCK. Clinical presentations and outcomes of Penicillium marneffei infections: a series from 1994 to 2004. Hong Kong Med J. 2008;14(2):103-109.
13. Chen SC, Sorrell TC, Meyer W. Aspergillus and Penicillium. Manual of clinical microbiology, 11th ed. ASM Press, Washington, DC. 2015, p 2030–2056.
14. Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev. 2006;19(1):95-110. doi: 10.1128/CMR.19.1.95-110.2006
15. Limper AH, Adenis A, Le T, Harrison TS. Fungal infections in HIV/AIDS. Lancet Infect Dis. 2017;17(11):e334-e343. doi: 10.1016/S1473-3099(17)30303-1. Epub 2017 Jul 31.
16. Wang PH, Wang HC, Liao CH. Disseminated Penicillium marneffei mimicking paradoxical response and relapse in a non-HIV patient with pulmonary tuberculosis. J Chin Med Assoc. 2015;78(4):258-260. doi: 10.1016/j.jcma.2013.11.009. Epub 2015 Mar 29.
17. De Monte A, Risso K, Normand AC, Boyer G, L'Ollivier C, Marty P, et al. Chronic pulmonary penicilliosis due to Penicillium marneffei: late presentation in a french traveler. J Travel Med. 2014;21(4):292-294. doi: 10.1111/jtm.12125. Epub 2014 May 11.
18. DiSalvo AF, Fickling AM, Ajello L. Infection caused by Penicillium marneffei: description of first natural infection in man. Am J Clin Pathol. 1973;60(2):259–263. doi:https://doi.org/10.1093/ajcp/60.2.259.
19. Chi XH, Xue YM, Wang QS, Li GP, Zhou HS, Qi YS. Diagnosis and treatment of diffusible Penicillium marneffei in human immunodeficiency virus-negative patients: A challenge for the physician. Indian J Med Microbiol. 2017;35(4):617-619. doi: 10.4103/ijmm.IJMM_15_418.
20. Hu Y1, Zhang J, Li X, Yang Y, Zhang Y, Ma J, Xi L. Penicillium marneffei infection: an emerging disease in mainland China. Mycopathologia. 2013;175(1-2):57-67. doi: 10.1007/s11046-012-9577-0. Epub 2012 Sep 17.
21. Walsh T, Hayden RT, Larone DH. 2018. Talaromyces (Penicillium) marneffei. In Larone’s medically important fungi: a guide to identification,6th ed. ASM Press, Washington, DC, p 176–177.
22. K. Supparatpinyo, P. Hirunsri, C. Uthammachai et al., An efficacy study of itraconazole in the treatment of Penicillium marneffei infection. J Med Assoc Thailand. 1992;75(12):688–691.
2. Xiang Y, Guo W, Liang K. An unusual appearing skin lesion from Penicillium marneffei infection in an AIDS patient in central China. Am J Trop Med Hyg. 2015;93(1):3. doi: 10.4269/ajtmh.14-0697.
3. Segretain G. [Penicillium marneffei n.sp., agent of a mycosis of the reticuloendothelial system]. Mycopathol Mycol Appl. 1959;11:327-353. doi: 10.1007/bf02089507.
4. Chander J. Talaromycosis. In A textbook of Medical Mycology. New Delhi: Mehta Publishers;2009;506-523.
5. Wang YF, Xu HF, Han ZG, Zeng L, Liang CY, Chen XJ, et al. Serological surveillance for Penicillium marneffei infection in HIV-infected patients during 2004-2011 in Guangzhou, China. Clin Microbiol Infect. 2015;21(5):484-489. doi: 10.1016/j.cmi.2014.12.014. Epub 2014 Dec 26.
6. Wong SY, Wong KF. Penicillium marneffei Infection in AIDS. Pathol Res Int. 2011;2011. 764293. doi: 10.4061/2011/764293.
7. Duong TA. Infection due to Penicillium marneffei, an emerging pathogen: review of 155 reported cases. Clin Infect Dis. 1996;23(1):125-130. doi: https://doi.org/10.1093/clinids/23.1.125.
8. Liu GN, Huang JS, Zhong XN, Zhang JQ, Zou ZX, Yang ML, et al. Penicillium marneffei infection within an osteolytic lesion in an HIV-negative patient. Int J Infect Dis. 2014;23:1-3. doi: 10.1016/j.ijid.2013.12.019. Epub 2014 Mar 19.
9. Qiu Y, Zhang J, Liu G, Zhong X, Deng J, He Z, et al. A case of Penicillium marneffei infection involving the main tracheal structure. BMC Infect Dis. 2014;14:242. doi: 10.1186/1471-2334-14-242.
10. Supparatpinyo K, Khamwan C, Baosoung V, Nelson KE, Sirisanthana T, Disseminated Penicillium marneffei infection in Southeast Asia. Lancet, 1994;344(8915):110-113. doi: https://doi.org/10.1016/S0140-6736(94)91287-4.
11. Ranjana KH, Priyokumar K, Singh TJ, Gupta CC, Sharmila L, Singh PN, Chakrabarti A. Disseminated Penicillium marneffei infection among HIV-infected patients in Manipur state, India. J Infect. 2002;45(4):268-271. doi: https://doi.org/10.1053/jinf.2002.1062.
12. Wu TC, Chan JWM, Ng CK, Tsang DNC, Lee MP, Li PCK. Clinical presentations and outcomes of Penicillium marneffei infections: a series from 1994 to 2004. Hong Kong Med J. 2008;14(2):103-109.
13. Chen SC, Sorrell TC, Meyer W. Aspergillus and Penicillium. Manual of clinical microbiology, 11th ed. ASM Press, Washington, DC. 2015, p 2030–2056.
14. Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T. Penicillium marneffei infection and recent advances in the epidemiology and molecular biology aspects. Clin Microbiol Rev. 2006;19(1):95-110. doi: 10.1128/CMR.19.1.95-110.2006
15. Limper AH, Adenis A, Le T, Harrison TS. Fungal infections in HIV/AIDS. Lancet Infect Dis. 2017;17(11):e334-e343. doi: 10.1016/S1473-3099(17)30303-1. Epub 2017 Jul 31.
16. Wang PH, Wang HC, Liao CH. Disseminated Penicillium marneffei mimicking paradoxical response and relapse in a non-HIV patient with pulmonary tuberculosis. J Chin Med Assoc. 2015;78(4):258-260. doi: 10.1016/j.jcma.2013.11.009. Epub 2015 Mar 29.
17. De Monte A, Risso K, Normand AC, Boyer G, L'Ollivier C, Marty P, et al. Chronic pulmonary penicilliosis due to Penicillium marneffei: late presentation in a french traveler. J Travel Med. 2014;21(4):292-294. doi: 10.1111/jtm.12125. Epub 2014 May 11.
18. DiSalvo AF, Fickling AM, Ajello L. Infection caused by Penicillium marneffei: description of first natural infection in man. Am J Clin Pathol. 1973;60(2):259–263. doi:https://doi.org/10.1093/ajcp/60.2.259.
19. Chi XH, Xue YM, Wang QS, Li GP, Zhou HS, Qi YS. Diagnosis and treatment of diffusible Penicillium marneffei in human immunodeficiency virus-negative patients: A challenge for the physician. Indian J Med Microbiol. 2017;35(4):617-619. doi: 10.4103/ijmm.IJMM_15_418.
20. Hu Y1, Zhang J, Li X, Yang Y, Zhang Y, Ma J, Xi L. Penicillium marneffei infection: an emerging disease in mainland China. Mycopathologia. 2013;175(1-2):57-67. doi: 10.1007/s11046-012-9577-0. Epub 2012 Sep 17.
21. Walsh T, Hayden RT, Larone DH. 2018. Talaromyces (Penicillium) marneffei. In Larone’s medically important fungi: a guide to identification,6th ed. ASM Press, Washington, DC, p 176–177.
22. K. Supparatpinyo, P. Hirunsri, C. Uthammachai et al., An efficacy study of itraconazole in the treatment of Penicillium marneffei infection. J Med Assoc Thailand. 1992;75(12):688–691.
CITATION
DOI: 10.17511/jopm.2019.i11.20
Published: 2019-11-30
How to Cite
Chalana, M., & Oberoi, L. (2019). Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis coinfection in a HIV negative patient in Amritsar Punjab, India. Tropical Journal of Pathology and Microbiology, 5(11), 959-961. https://doi.org/10.17511/jopm.2019.i11.20
Section
Case Report
OAI - Open Archives Initiative
