Comparison of different cytological tools with conventional diagnostic methods in diagnosis of Helicobacter pylori infection
Background: Helicobacter Pylori (H pylori) infection causes severe gastrointestinal morbidity and mortality worldwide.
Objective: To evaluate the usefulness of gastric crush cytology and imprint cytology with conventional histopathology and rapid urease tests. Materials and Methods: Antral biopsies were collected from 130 patients and evaluated for H Pylori infection by imprint cytology, crush cytology and histopathological examination by different stains and rapid urease test.
Results: 118 patients showed H. pylori infection by two or more methods. Giemsa histology, showed highest sensitivity, specificity, Positive predictive value (PPV), negative predictive value (NPV) and Youden’s index (YI). Among cytology methods, crush cytology was found more effective in detecting H pylori infection.
Conclusion: H. pylori infection is associated with gastric mucosa changes like chronic active gastritis, atrophy, intestinal metaplasia, ulceration and carcinoma. Imprint cytology has high sensitivity and comparable predictive values to conventional diagnostic tools-histopathological examination and rapid urease test in detection of H. pylori infection.
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