Role of fine needle aspiration cytology in the diagnosis of soft tissue tumors - a prospective study
Abstract
Background: Soft tissue can be defined as non- epithelial, extraskeletal tissues of the body exclusive of reticulo-endothelial system, glia and supporting tissues of various parenchymal organs. The annual incidence of soft tissue tumor is 1.4 per 1,00,000 population. FNAC is almost painless, easy to perform, safe and cost effective procedure without any anaesthesia and acts as a useful diagnostic technique in the initial diagnosis of tumors.
Aims:To study the utility of fine needle aspiration cytology (FNAC) in the diagnosis of soft tissue tumours and in distinguishing benign or malignant tumors.
Material and Methods: 105 cases of soft tissue tumors were included in this study for cytologic and histologic correlation. FNAC air dried smears were stained with Leishman stain and 95% ethanol fixed smears were stained with H&E. Smearswere categorised as benign, malignant, inconclusive or undetermined along with specific subtyping of the lesion. All diagnostic FNAC results were compared for diagnostic concordance using histology results as the gold standard.
Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 82.6%, 100%, 100%, 93.3% and 95% respectively.
Conclusion: FNAC is an important preliminarydiagnostic tool in palpable soft tissue tumors with high degree of correlation with histopathology report.
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References
2. Hajdu SI: Diagnosis of soft tissue sarcomas on aspiration smears, editorial,ActaCytol.1996;40:607-608. doi:10.1159/000333926
3.Weiss SW, Goldblum JR. General Considerations. Ch-1 In: Enzinger and Weiss Soft tissue tumors. 4th edition, St.Louis: Mosby, 2001;1-19
4.Rydholm A, Berg NO. Epidemiology of Soft tissue sarcoma in locomotor system. A retrospective population based study of interrelationships between clinical and morphological variables. Acta Pathol Microbiol Immunol Scand. 1984; 92 (5): 363- 374.
5. Ackerman M, DomanskiH.Soft tissues. In:Orell SR, Sterrett GF, editors. Orell and Sterrett’s Fine Needle Aspiration Cytology. 5th ed. Edinburgh, Scotland: Churchill Livingstone;2012.pp 387-400.
6.Rosenberg AE, Bones, joints and soft tissue tumors editors. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadephia, Pa, USA: Saunders; 2010. pp. 235-249.
7.Rekhi B, Gorad BD. Kakade AC, ChinoyR.Scope of FNAC in the diagnosis of soft tissue tumors- a study from a tertiary cancer referral centre in India. Cyto J. 2007;4:20.doi: 10.1186/1742-6413-4-20
8.Dey P, Mallik MK, Gupta SK, Vasishta RK. Role of fine needle aspiration cytology in the diagnosis of soft tissue tumors and tumor like lesions.Cytopathol. 2004; 15(1):32-37. doi:https://doi.org/10.1046/j.0956-5507. 2003. 00102.x
9.Roy S,Manna AK, PathakS,GuhaD.Evaluation of fine needle aspiration cytology and its correlation with histopathological findings in soft tissue tumors.J Cytol. 2007;24(1):37-40.
10. Parajuli S, LakheyM.Efficacy of fine needle aspiration cytology in diagnosing soft tissue tumors. J Pathol Nepal. 2012;2(4):305-308.doi: https://doi. org/ 10. 3126/jpn.v2i4.6884
11.Orell SR, Sterrett GF, Walters M, Whitaker D: Manual and Atlas Of Fine Needle Aspiration Cytology, Churchill Livingstone,London, fourth ed.,2005,409-432
12. Gonzalez – Campora R. Fine needle aspiration cytology of soft tissue tumours. ActaCytol.2000; 44 (3):337 – 343.doi: https://doi.org/10.1159/000328475
13.Maitra A, Ashfaq R, Saboorian MH, Lindberg G, Gokaslan ST. The role of fine – needle aspiration biopsy in the primary diagnosis of mesenchymal lesions: a community hospital – based experience. Cancer. 2000; 90(3):178–185.
14. Enzinger and Weiss’s Soft Tissue Tumours, ed. SW Weiss and JR Goldblum, Mosby Co., St Louis, fourth ed, 2001, pp:147-188.
15. Keiko Nagira, Tetsuji Yamamoto, Toshihiro Akisue. Reliability of fine – needle aspiration biopsy in the initial diagnosis of soft–tissue lesions.Diagn Cytopathol. 2002; 27(6):354 – 361.doi:https://doi. org/ 10. 1002/dc.10200.
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