Synchronous primary cancer of the thyroid and breast
Keywords:
Synchronous, FNAC, papillary thyroid
Abstract
Background: The present case is of a synchronous primary classical thyroid carcinoma and primary ductal carcinoma of the breast in a 57 year old lady. Though the incidence of both thyroid cancer and breast cancer have been rising in recent years, it is very rare to find a single person with both of these cancers.
Case summary: Patient underwent total thyroidectomy and right breast lump excision. Post operative histopathological examination identified papillary carcinoma thyroid, classical type, of the right lobe with metastasis to central compartment lymph nodes and invasive ductal carcinoma of the right breast. Now the patient is on regular follow up. Thus the aim of the current report was to improve the understanding of synchronous primary tumors of the thyroid and breast by presenting a review of the associated literature regarding breast and thyroid carcinoma.
Conclusion: Although synchronous primary tumors of the thyroid and breast are very rare, they remain a possibility, therefore more attention should be paid to this cancer.
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References
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2.JemalA, BrayF, CenterMM, Ferlay J, WardE, Forman D. Global cancer statistics.CACancerJ Clin. 2011;61 (2): 69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
3. Arer İM, Yabanoğlu H, Kuş M, Akdur A, Avcı T. Retrospective Analysis of Patients with Synchronous Primary Breast and Thyroid Carcinoma. Eur J Breast Health [Internet] 2018;14(2):80-84.doi: 10.5152/ejbh. 2018.3853.
4. Ghosh S, Rao PB, Sarkar S, Kotne S, Turlapati SP, Mishra A. A rare case of a synchronous anaplastic carcinoma thyroid with ductal carcinoma breast. Case Rep Oncol Med. 2014;2014. doi: http://dx.doi.org/10. 1155/2014/468159
5. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1-133. doi: 10. 1089 / thy.2015.0020.
6.Horváth Z, Boér K, Dank M, Kahán Z, Kocsis J, Kövér E, et al. Systemic therapy of breast cancer: practice guideline. Magy Onkol. 2016;60(3):241-57.
7. Bittorf B, Kessler H, Merkel S, Brückl W, Wein A, Ballhausen WG, et al. Multiple primary malignancies: An epidemiological and pedigree analysis of 57 patients with at least three tumours. Eur J Surg Oncol. 2001; 27 (3): 302-13. doi:10.1053/ejso.2001.1112
8.Huang J, Walker R, Groome PG, Shelley W, Mackillop WJ. Risk of thyroid carcinoma in a female population after radiotherapy for breast carcinoma. Cancer. 2001;92(6):1411-8. DOI:10.1002/ 1097-0142 (20010915) 92: 6<1411::aid-cncr1464> 3.0. co; 2-9
9. Van Fossen VL, Wilhelm SM, Eaton JL, McHenry CR. Association of thyroid, breast and renal cell cancer: a population-based study of the prevalence of second malignancies. Ann Surg Oncol. 2013;20(4):1341-7. doi: 10.1245/s10434-012-2718-3. Epub 2012.
10. Simon MS, Tang MT, Bernstein L, Norman SA, Weiss L, Burkman RT, et al. Do thyroid disorders increase the risk of breast cancer? Cancer Epidemiol Biomarkers Prev 2002 Dec 1;11(12):1574-8.
11.Liu L, Shi J, Mao F, Wei J, Fu D, Zhang J. Synchronous primary cancers of the thyroid and breast: a case report and review of the literature. Oncol Lett. 2015;9(1):351-4. doi: 10.3892/ol.2014.2625
12. Gaertner FC, Rohde F, Mueller J, Blechert B, Janssen KP, Essler M. Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma. Int J Cancer. 2009 ;125(12):2783-91. doi: 10.1002/ijc.24705.
13. Smith VE, Franklyn JA, Mc Cabe CJ. Expression and function of the novel proto-oncogene PBF in thyroid cancer: a new target for augmenting radioiodine uptake.J Endocrinol. 2011;210(2):157-63. doi: 10.1530/ JOE-11-0064. Epub 2011.
14.Clark DW, Mitra A, Fillmore RA, Jiang WG, Samant RS, Fodstad O, et al. NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. Curr Cancer Drug Targets. 2008; 8(5): 421-30. doi: 10.2174/156800908785133196
15. Knappskog S, Myklebust LM, Busch C, Aloysius T, Varhaug JE, Lønning PE, et al. RINF (CXXC5) is overexpressed in solid tumors and is an unfavorable prognostic factor in breast cancer. Ann Oncol. 2011; 22 (10):2208- 15. doi: 10.1093/annonc/mdq737.Epub 2011 Feb 16.
16. Ito Y, Miyauchi A, Kihara M, Kobayashi K, Miya A. Prognostic values of clinical lymph node metastasis and macroscopic extrathyroid extension in papillary thyroid carcinoma. Endocr J. 2014;61(8):745-50. doi: https://doi.org/10.1507/endocrj.EJ14-0138 Epub 2014 Apr 17.
17. Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, et al. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Hum Mol Genet. 2012;21(2):300-10. doi: 10.1093/ hmg/ddr459. Epub 2011 .
18. Agarwal DP, Soni TP, Sharma OP, Sharma S. Synchronous malignancies of breast and thyroid gland: a case report and review of literature. Journal of cancer research and therapeutics. 2007; 3(3):172. doi: 10.4103/ 0973-1482.37413
19. Kim C, Bi X, Pan D, Chen Y, Carling T, Ma S, et al. The risk of second cancers after diagnosis of primary thyroid cancer is elevated in thyroid microcarcinomas. Thyroid. 2013; 23(5): 575-82. doi: 10.1089/thy.2011. 0406. Epub 2013.
20. Zhong J, Lei J, Jiang K, Li Z, Gong R, Zhu J. Synchronous papillary thyroid carcinoma and breast ductal carcinoma: A rare case report and literature review. Med. 2017; 96(7).e6114. doi: 10.1097/MD. 000 0000000006114.
CITATION
DOI: 10.17511/jopm.2019.i07.08
Published: 2019-07-31
How to Cite
Dr. Rakshitha H.M., Dr. Suma M.N., Dr. Ravi Arjunan, Dr. Malathi M, Dr. Priya D., & Dr. Premalata C.S. (2019). Synchronous primary cancer of the thyroid and breast. Tropical Journal of Pathology and Microbiology, 5(7), 461-465. https://doi.org/10.17511/jopm.2019.i07.08
Issue
Section
Case Report
OAI - Open Archives Initiative
