ER, PR, M1B1 index and HER2/NEU status in 100 cases of Breast Carcinoma

  • Dr. Priti P. Trivedi Department of Pathology, Gujarat Cancer Research Institute, Ahmedabad, Gujrat, India.
  • Dr. Deepak K. Goel Department of Pathology, Gujarat Cancer Research Institute, Ahmedabad, Gujrat, India.Dr. Deepak K. Goel
  • Dr. Silky Patel Department of Pathology, Gujarat Cancer Research Institute, Ahmedabad, Gujrat, India.
  • Dr. Dhaval H. Jetly Department of Pathology, Gujarat Cancer Research Institute, Ahmedabad, Gujrat, India.
Keywords: Breast carcinoma, ER/PR, Her2/neu, M1B1 index, Histological grade

Abstract

Background: Breast carcinomas are the most common cancers in women in our country. There have been various studies about the markers like ER/PR, HER2/NEU, HRAS, p53, Ki67 predicting response along with morphology and mitotic count.

Aim: To find out the prevalence of various molecular subtypes of breast cancers and correlate molecular subtypes and M1B1 index with histological features, clinical stage and other prognostic factors.

Materials and Methods: It is a prospective study of 100 cases of breast cancer operated in our hospital. All specimens were grossed and then stained using hematoxylin and eosin staining. They were staged according to TNM classification and further processed for immunostaining(ER, PR, Her2/neu and M1B1).

Results: Luminal A is the most common subtype and is associated with lower clinical stage.Higher M1B1 index is associated with higher aggressiveness.

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ER, PR, M1B1 index and HER2/NEU status in 100 cases of Breast Carcinoma
CITATION
DOI: 10.17511/jopm.2019.i03.08
Published: 2019-03-31
How to Cite
Dr. Priti P. Trivedi, Dr. Deepak K. Goel, Dr. Silky Patel, & Dr. Dhaval H. Jetly. (2019). ER, PR, M1B1 index and HER2/NEU status in 100 cases of Breast Carcinoma. Tropical Journal of Pathology and Microbiology, 5(3), 156-162. https://doi.org/10.17511/jopm.2019.i03.08
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Original Article