Prevalence of Hepatitis C Virus among blood donors in Blood Bank of Jhalawar Hospital & Medical College Society, Jhalawar Rajasthan
Keywords:
Blood donors, HCV, Replacement donors, Voluntary donors
Abstract
Introduction: Hepatitis C infection continue to be a threat to safe transfusion practices. This study aims to determine the prevalence of Hepatitis- C virus (HCV) among voluntary and replacement blood donors in Blood Bank of Jhalawar Hospital & Medical College Society, Jhalawar, Rajasthan.
Material and Methods: A retrospective review of donors record covering the period between Jan 2017 to Dec 2017 at Jhalawar Hospital & Medical College Society, Jhalawar, Rajasthan. The blood collections were taken from the voluntary donors at total 69 blood donation camp and as well as from replacement donors and voluntary donors at blood bank. The blood samples were then obtained by standard procedures of venepuncture. Total 16495 blood donors screened over the period of one year. Antibodies to Hepatitis C virus in serum/plasma is detected by rapid test kit.
Results: 34 out of 16495 donor population were positive for Hepatitis C (Prevalence 0.2%).
Conclusion: Replacement donors were higher prevalence than the voluntary donors. So, the present study concludes that motivating voluntary blood donors by conducting voluntary blood donation camp is the most effective way of ensuring adequate supplies of safe blood and blood components for transfusion.
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References
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25. Kucirka LM, Sarathy H, Govindan P, et al. Risk of window period hepatitis-C infection in high infectious risk donors: systematic review and meta-analysis. Am J Transplant. 2011 Jun;11(6):1188-200. doi: 10.1111/j.1600-6143.2011.03460.x.Epub 2011 Mar 14.[pubmed]
26. Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009 Jul;119(7):1745-54. doi: 10.1172/JCI39133. Epub 2009 Jul 1.[pubmed]
27. Singer AL, Kucirka LM, Namuyinga RHC, Subramanian AK, Segev DL. The high risk donor: Viral infections in solid organ transplantation. Current Opinion Org Transpl. 2008 aug;13(4):400–4.doi: 10.1097/MOT.0b013e3283094ba3.
28. Chatterjee K, Coshic P, Borgohain M, et al. Individual donor nucleic acid testing for blood safety against HIV-1 and hepatitis B and C viruses in a tertiary care hospital. Natl Med J India. 2012 Jul-Aug;25(4):207-9.[pubmed]
2. Choudhury N, Desai P. Blood bank regulations in India. Clin Lab Med. 2012 Jun;32(2):293-9. doi: 10.1016/j.cll.2012.04.002.[pubmed]
3. Shekhar, S. Hepatitis C Virus Infection in the Indian Sub-Continent, January 2018;83-95. https://doi.org/10.1016/b978-0-12-803233-6.00008-4
4. Lemon SM, Walker C, Alter MJ, Min Kyung Y. Hepatitis C virus. In: Knipe DM, Howley PM, editors. Field's Virology. 5th ed. Netherlands, Philadelphia: Wolters Kluwer, Lippincott Williams & Wilkins; 2007. pp. 1253–304
5. Alter MJ. Epidemiology of hepatitis C virus infection. World J Gastroenterol. 2007 May 7;13(17):2436-41.[pubmed]
6. Khodabandehloo M, Roshani D, Sayehmiri K. Prevalence and trend of hepatitis C virus infection among blood donors in Iran: A systematic review and meta-analysis. J Res Med Sci. 2013 Aug;18(8):674-82.[pubmed]
7. Giri PA, Deshpande JD, Phalke DB, et al. Seroprevalence of transfusion transmissible infections among voluntary blood donors at a tertiary care teaching hospital in rural area of India. J Family Med Prim Care. 2012 Jan;1(1):48-51. doi: 10.4103/2249-4863.94452.[pubmed]
8. Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol. 2001 Oct;44(4):409-12.[pubmed]
9. Meena M, Jindal T, Hazarika A. Prevalence of hepatitis B virus and hepatitis C virus among blood donors at a tertiary care hospital in India: a five-year study. Transfusion. 2011 Jan;51(1):198-202. doi: 10.1111/j.1537-2995.2010.02801.x.[pubmed]
10. Gupta PK, Kumar H, Basannar DR, Jaiprakash M. Transfusion transmitted infections in the armed forces: prevalence and trends. MJAFI. 2006; 62(4):348-50. doi: 10.1016/S0377-1237(06)80105-X
11. Narayankar SL, Maindad VC (2016). Prevalence of Hepatitis C among Voluntary Blood Donors in Mumbai, 04(11), 13717. https://doi.org/10.18535/jmscr/v4i11.35
12. Kaur H, Manjari M, Thaman RG, Singh G, Prevalence of markers of hepatitis c virus among the blood donors J Clin Diagn Res 2012 6(6):959-62.
13. Poddar N, Lenka PR, Chayani N, Mohanty S, Mallick B, Pattnaik D, Seroprevalence of hepatitis-c virus in blood donors and high risk individuals J Evol Med and Dent Sci 2012 1(6):959-63.
14. Bhawani Y, Rao PR, Sudhakar V, Seroprevalence of transfusion transmissible infections among blood donors in a tertiary care hospital of Andhra Pradesh Biology and Medicine 2010 2(4):45-8.
15. Kochhar AK, Duggal G. Trend in seroprevalence of hepatitis C virus infection among blood donors of southern Haryana. JARBS 2012 4:219-22.
16. Gupta N, Kumar V, Kaur A. et al. Seroprevalence of HIV, HBV, HCV and syphilis in voluntary blood donors. Indian J Med Sci. 2004 Jun;58(6):255-7.[pubmed]
17. Bhattacharya P, Chandra PK, Datta S, Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007 Jul 21;13(27):3730-3.[pubmed]
18. Chandra T, Kumar A, Gupta A. Prevalence of transfusion transmitted infections in blood donors: an Indian experience. Trop Doct. 2009 Jul;39(3):152-4. doi: 10.1258/td.2008.080330.[pubmed]
19. Arora D, Arora B, Khetarpal A. Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana. Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):308-9. doi: 10.4103/0377-4929.64295.[pubmed]
20. Thakral B, Marwaha N, Chawla YK, et al. Prevalence & significance of hepatitis C virus (HCV) seropositivity in blood donors. Indian J Med Res. 2006 Oct;124(4):431-8.[pubmed]
21. Mukhopadhya A. Hepatitis C in India. J.Biosci. 2008; 33:465-73.[pubmed]
22. Das BK, Gayen BK, Aditya S, Chakrovorty SK, Datta PK, Joseph A. Seroprevalence of Hepatitis B, Hepatitis C, and human immunode fi ciency virus among healthy voluntary first time blood donors in Kolkata. Ann Trop Med Public Health. 2011; 4(2):86-90.DOI: 10.4103/1755-6783.85758
23. Makroo RN, Walia RS, Chowdhry M, et al. Seroprevalence of anti-HCV antibodies among blood donors of north India. Indian J Med Res. 2013;138:125-8.[pubmed]
24. Yeung CY, Lee HC, Chan WT, Jiang CB, Chang SW, Chuang CK. Vertical transmission of hepatitis C virus: Current knowledge and perspectives. World J Hepatol 2014 Sep 27;6(9);643-51. doi: 10.4254/wjh.v6.i9.643
25. Kucirka LM, Sarathy H, Govindan P, et al. Risk of window period hepatitis-C infection in high infectious risk donors: systematic review and meta-analysis. Am J Transplant. 2011 Jun;11(6):1188-200. doi: 10.1111/j.1600-6143.2011.03460.x.Epub 2011 Mar 14.[pubmed]
26. Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009 Jul;119(7):1745-54. doi: 10.1172/JCI39133. Epub 2009 Jul 1.[pubmed]
27. Singer AL, Kucirka LM, Namuyinga RHC, Subramanian AK, Segev DL. The high risk donor: Viral infections in solid organ transplantation. Current Opinion Org Transpl. 2008 aug;13(4):400–4.doi: 10.1097/MOT.0b013e3283094ba3.
28. Chatterjee K, Coshic P, Borgohain M, et al. Individual donor nucleic acid testing for blood safety against HIV-1 and hepatitis B and C viruses in a tertiary care hospital. Natl Med J India. 2012 Jul-Aug;25(4):207-9.[pubmed]
CITATION
DOI: 10.17511/jopm.2019.i03.06
Published: 2019-03-31
How to Cite
Dr. Manish Kumar, & Dr. Yogendra Madan. (2019). Prevalence of Hepatitis C Virus among blood donors in Blood Bank of Jhalawar Hospital & Medical College Society, Jhalawar Rajasthan. Tropical Journal of Pathology and Microbiology, 5(3), 144-149. https://doi.org/10.17511/jopm.2019.i03.06
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