Serological profile of febrile rash in patients at a tertiary care hospital in Telangana
Keywords:
Fever, Rash, Serology, Age
Abstract
Introduction: Evaluating the patients who presents with fever and rash can be challenging because the differential diagnosis is extensive and includes minor and life-threatening illnesses.
Materials & Methods: A total of 300 patients with provisional diagnosis of acute febrile illness were evaluated during the period of August 2016 to July 2017 at Sir Ronald Ross Institute of Tropical and Communicable Diseases, Nallakunta, Hyderabad. All the clinically suspected cases of febrile rash were subjected for serological study.
Results: Most commonly affected age group is 14-40 years. Fever is the most common symptom. NS1ag was detected in 44.7% of cases. Secondary dengue infection is 12.3%. IgM is positive in 57.1% of chikungunya cases. The chicken pox IgM positivity was reported in 80% of cases. About 82.8% of measles serologically confirmed cases.
Conclusion: Diagnosis can be established serologically in 63.6% of cases there by emphasizing the need for Clinico-serological correlation of rashes. Acute febrile illness comprises infection due to malaria, influenza, leptospirosis, scrub typhus, typhoid fever, and dengue, of which some infections necessitate specific treatment. As antibiotics will be required to treat bacterial diseases, knowing the viral etiology will help in avoiding unnecessary administration of antibiotics.
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References
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3. Prafulla Dutta, Siraj A. Khan, Jani Borah and Jagadish Mahanta. Demographic and Clinical Features of Patients with Dengue in North eastern Region of India: A Retrospective Cross-Sectional Study during 2009-2011. Journal of Virology & Microbiology. Vol. 2012 (2012), Article ID 786298, 11 pages .[pubmed]
4. Manjunath J. Kulkarni, Vijaya Sarathi, Vikas Bhalla, Deepak Shivpuri &UshaAcharya. Clinico-Epidemiological Profile of Children Hospitalized with Dengue. Indian J Pediatr (2010) 77:1103-1107.
5. Datta S, Wattal C. Dengue NS1 antigen detection: a useful tool in early diagnosis of dengue virus infection. Indian J Med Microbiol. 2010 Apr-Jun;28(2):107-10. doi: 10.4103/0255-0857.62484.[pubmed]
6. Hati AK. Dengue serosurveillance in Kolkata, facing an epidemic in West Bengal, India. J Vector Borne Dis. 2009 Sep;46(3):197-204.[pubmed]
7. Ahmed Mohamed Ashi. The prevalence of dengue virus serotypes in asymptomatic blood donors reveals the emergence of serotype 4 in Saudi Arabia. Virology Journal 2017;14:107
8. Neeraja M, Lakshmi V, Teja VD, et al. Sero diagnosis of dengue virus infection in patients presenting to a tertiary care hospital. Indian J Med Microbiol. 2006 Oct;24(4):280-2.[pubmed]
9. Ashwini Kumar, Chythra R Rao, Vinay Pandit, Seema Shetty, Chanaveerappa Bammigatti, Charmaine Minoli Samarasinghe. Clinical Manifestations and Trend of Dengue Cases Admitted in a Tertiary Care Hospital, Udupi District, Karnataka. Indian Journal of Community Medicine 2010;July 35(3):386-390.
10. Cucunawangsih, Lugito NP, Kurniawan A. Immunoglobulin G (IgG) to IgM ratio in secondary adult dengue infection using samples from early days of symptoms onset. BMC Infect Dis. 2015 Jul 21;15:276. doi: 10.1186/s12879-015-1022-9.[pubmed]
11. Borgherini G, Poubeau P, Staikowsky F, et al. Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis. 2007 Jun 1;44(11):1401-7. Epub 2007 Apr 18.DOI:10.1086/517537.[pubmed]
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14. Galate LB, Agrawal SR, Shastri JS, et al. Chikungunya Fever Among Patients with Acute Febrile Illness Attending a Tertiary Care Hospital in Mumbai. J Lab Physicians. 2016 Jul-Dec;8(2):85-9. doi: 10.4103/0974-2727.180787.[pubmed]
15. Ahmad N. Chikungunya Fever - epidemic in rural maharashtra. Indian J Community Med. 2009 Oct;34(4):372-4. doi: 10.4103/0970-0218.58409.[pubmed]
16. Patil SS, Patil SR, Durgawale PM, et al. A study of the outbreak of Chikungunya fever. J Clin Diagn Res. 2013 Jun;7(6):1059-62. doi: 10.7860/JCDR/2013/5330.3061. Epub 2013 Apr 10.[pubmed]
17. Singh MP, Chandran C, Sarwa A, et al. Outbreak of chickenpox in a Union Territory of North India. Indian J Med Microbiol. 2015 Oct-Dec;33(4):524-7. doi: 10.4103/0255-0857.167335.[pubmed]
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20. Tepebaşili I, Caksen H, Odabaş D, et al. Measles is still a severe problem in eastern Turkey. J Emerg Med. 2004 Jul;27(1):87-8.[pubmed]
21. Anis-ur-Rehman, Siddiqui TS, Idris M. Clinical outcome in measles patients hospitalized with complications. J Ayub Med Coll Abbottabad. 2008 Apr-Jun; 20(2):14-6.[pubmed]
22. Deepa K.S. Clinical Profile of Measles in Children admitted to a Rural Tertiary Care Hospital. Journal of Evolution of Medical and Dental Sciences 2015; 4(46): 7995-7999.
23. Michel Y, Saloum K, Tournier C, et al. Rapid molecular diagnosis of measles virus infection in an epidemic setting. J Med Virol. 2013 Apr;85(4):723-30. doi: 10.1002/jmv.23515. Epub 2013 Jan 30.[pubmed]
24. Surender N Gupta, Naveen Gupta, Shivani Gupta. A Mixed Outbreak of Rubeola-Rubella in District Kangra of Northern India. Journal of Family Medicine and Primary Care 2013, 2 (4): 354-9.[pubmed]
25. Hashmi S, Singh A K, Rawat V, Kumar M, Mehra A K, Singh R K. Measles outbreak investigation in Dwarahat block of District Almora, Uttarakhand. Indian J Med Microbiol2015;33:406-9.[pubmed]
CITATION
DOI: 10.17511/jopm.2018.i07.11
Published: 2018-11-30
How to Cite
Dr. Afroze Sultana, & Dr. M.L. Kavitha Latha. (2018). Serological profile of febrile rash in patients at a tertiary care hospital in Telangana. Tropical Journal of Pathology and Microbiology, 4(7), 545-550. https://doi.org/10.17511/jopm.2018.i07.11
Section
Original Article
OAI - Open Archives Initiative
