Seroprevalence of Australia antigen (HbsAg) among blood donors in local population
Abstract
Introduction:Transfusion of Blood & Blood Components is one of the four recognized modes of Hepatitis B virus infection andHBsAg or Australia Antigen in the serum is the earliest marker of active HBV infection (acute/chronic) being detectable even before elimination of transaminases and onset of clinical illness. Various strategies are being used to reduce this transfusion transmitted infection.
Objectives:To determine the Seroprevalence of HBsAg among blood donors in and around Junagadh (Gujarat) and to compare it withthat of other regions in India.
Methods:The study was conducted on apparently healthy blood donors over a period of 3 years from January-2015 to December-2017 at Blood Bank, Department of Pathology, GMERS Medical College and Hospital, Junagadh in order to assess the prevalence of hepatitis B virus infection. A total number of 18368 blood donors were included in this study. Both rapid HBsAg card test and HBsAg ELISA test were used for this study purpose.
Result:Out of 18368 donors, 14102 (76.77%) were in-house donors and 4266 (23.23%) were outdoor-camp donors. 17346 (94.44%) were males & 1022 (5.56%) were females. Out of 18368 blood units, 487 (2.65%) were discarded and out of them 109 (22.38%) were HBsAg reactive. The Seroprevalence of HBsAg was found to be 0.59%.
Conclusion:Blood Donors areoftenfound to be reactive for Australia Antigen and others. In order to reduce this Seroprevalence, more sensitive screening assays and appropriate donor selection are must.
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References
2. Karandeep Singh, Sudha Bhat, ShameeShastry. Trend in Seroprevalence of Hepatitis B virus infection among blood donors of coastal Karnataka, India. J Infect Dev Ctries 2009;3(5) : 376-379.[pubmed]
3. WHO global health situation projection and estimates. 1992; WHO Geneva 1992.[pubmed]
4. Glynn SA, Kleinman SH, Wright DJ, et al. International application of the incidence rate/window period model. Transfusion. 2002 Aug;42(8):966-72.[pubmed]
5. Doddy RY, Notari EP, Stamer SL. Current prevalence and incidence of infectious disease markers and estimated window period risk in the American Red Cross Blood Donor Population. Transfusion;2002;42:238-40.
6. Klein HG. Will blood transfusion ever be safe enough? JAMA. 2000 Jul 12;284(2):238-40.[pubmed]
7. Bhattacharya P, Chandra PK, Datta S, et al. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007 Jul 21;13(27):3730-3.[pubmed]
8. Srikrishna A, Sitalakshmi S, Damodar P. How safe are our safe donors? Indian J Pathol Microbiol. 1999 Oct;42(4):411-6.[pubmed]
9. Chattoraj A, Behl R, Kataria VK. Infectious Disease Markers in Blood Donors. Med J Armed Forces India. 2008 Jan;64(1):33-5. doi: 10.1016/S0377-1237(08)80142-6. Epub 2011 Jul 21.[pubmed]
10. Karandeep Singh, Sudha Bhat, ShameeShastry. Trend in seroprevalence of Hepatitis B virus infection among blood donors of coastal Karnataka, India. J Infect Dev Ctries; 2009; 3(5): 376-379.[pubmed]
11. Gagandeep Kaur, SabitaBasu, Ravneet Kaur, Paramjeet Kaur, Shailja Garg. Patterns of infections among blood donors in a tertiary care centre: A retrospective study . The National Medical Journal of India;2010;23(3):147 -49.
12. Gulia S, Panda S, Sitaramam E, Reddy K. Seroprevalence Of Hepatitis B Virus Infection Among Blood Donors In Local Population. The Internet Journal of Pathology. 2010; Volume 12 Number.
13. Jadeja P, Kaur A, Shekha H. Trend in Seroprevalance of Hepatitis B Virus infection among blood donors at a Tertiary Care Centre of Rajasthan, India. National journal of Medical Research, 2014- volume 4,issue 3:page no-205 to 207
14. Allain JP, Candotti D, Soldan K, et al. The risk of hepatitis B virus infection by transfusion in Kumasi, Ghana. Blood. 2003 Mar 15;101(6):2419-25. Epub 2002 Oct 17.[pubmed]
15. Lt Col PK Gupta, Col H Kumar, Mr. Basannar , Brig M Jaiprakash . Transfusion Transmitted Infections in Armed Forces : Prevalence and Trends :MJAFI;2006;62:348–350
16. Arthur RR, Hassan NF, Abdallah MY, et al. Hepatitis C antibody prevalence in blood donors in different governorates in Egypt. Trans R Soc Trop Med Hyg. 1997 May-Jun;91(3):271-4.[pubmed]
17. Nilima S., Sawke, G.K., Chawla, S. Seroprevalence of common transfusion transmitted infections among blood donors. People’s J. Sci. Res.2010; 3(1): 5–7.
18. Suresh B Sonth, Shilpa Gokale, Deepa Hadapad and Shivakumar S. Solabannavar. Prevalence of Hepatitis B Virus Infection among Blood Donors. IJCMAS,2015;4(10):915-918.
19. Sharma RR, Cheema R, Vajpayee M, et al. Prevalence of markers of transfusion transmissible diseases in voluntary and replacement blood donors. Natl Med J India. 2004 Jan-Feb;17(1):19-21.[pubmed]
20. Kurien T, Thyagarajan SP, Jeyaseelan L, et al. Community prevalence of hepatitis B infection and modes of transmission in Tamil Nadu, India.Indian J Med Res. 2005 May;121(5):670-5.[pubmed]
21. Asim M, Ali R, Khan LA, et al. Significance of anti-HBc screening of blood donors and its association with occult hepatitis B virus infection: Implications for blood transfusion. Indian J Med Res. 2010 Sep;132:312-7.[pubmed]
22. Chandrasekaran S, Palaniappan N, Krishnan V, et al. Relative prevalence of hepatitis B viral markers and hepatitis C virus antibodies (anti HCV) in Madurai, south India. Indian J Med Sci. 2000 Jul;54(7):270-3.[pubmed]
23. Rodenas JG, Bacasent LC, Que ER. The prevalence of HBsAg(+) and anti HCV(+) and anti HCV(+) among healthy blood donors at East Avenue Medical Center, Quezon City. Phil J of Gastroenterology. 2006;2;64-70.
24. Patil AV, Pawar SD, Pratinidhi AK. Study of prevalence, trend and correlation between infections disease markers of blood donors. Indian Journal of Hematology and Blood Transfusion.1996;14:95-102.
25. Mohd Younus Shah,MohdMubarikNaqash, Faizan Younus Shah. Seroprevalence of hepatitis b in healthy blood donors at a teaching hospital of Kashmir (skims medical college and hospital Bemina, Srinagar): a restrospective study of five years. Int J Res Med Sci. 2016 Feb;4(2):509-511.
26. Asim M, Ali R, Khan LA, et al. Significance of anti-HBc screening of blood donors and its association with occult hepatitis B virus infection: Implications for blood transfusion. Indian J Med Res. 2010 Sep;132:312-7.[pubmed]
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