Diagnostic challenge of follicular thyroid carcinoma with insular component mixed with follicular patterned papillary carcinoma
Keywords:
Mixed follicular thyroid carcinoma, Insular component, Follicular papillary
Abstract
Thyroid tumours with mixed follicular histological components present a great challenge for pathologists. Poorly differentiated carcinoma (or insular carcinoma) is intermediate tumour between well differentiated and anaplastic carcinomas of thyroid which may be associated with papillary and follicular thyroid carcinoma. It is important to differentiate the insular component and medullary carcinoma. We present an uncommon case of mixed follicular thyroid carcinoma with an insular component and follicular papillary variant in a 30 year old female which cannot be accurately diagnosed without application of immunohistochemistry.
Downloads
Download data is not yet available.
References
1. Ishikawa Y. Ciliated muconodular papillary tumor of the peripheral lung: benign or malignant. Pathol. Clin. Med. (Byouri-to-Rinsho) 2002; 20:964–965. (In Japanese).
2. Ishikawa M, Sumitomo S, Imamura N, Nishida T, Mineura K, Ono K. Ciliated muconodular papillary tumor of the lung: report of five cases. Journal of Surgical Case Reports 2016;8:1–4. doi: 10.1093/jscr/rjw144.[pubmed]
3. Flieder DB, Thivolet-Bejui F, Popper H. Tumor of the lung. Benign epithelial lesions. In: Travis WD, Brambilla E, Mu¨ller-Hermelink HK, Harris CC, editors. World Health Organization classification of tumors: pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press 2004:78–81.
4. Nakamura S, Koshikawa T, Sato T, Hayashi K, Suchi T.Extremely well differentiated papillary adenocarcinoma of the lung with prominent cilia formation.Acta PatholJpn. 1992 Oct;42(10):745-50.[pubmed]
5. Kamata T, Yoshida A, Kosuge T, Watanabe S, Asamura H, Tsuta K. Ciliated muconodular papillary tumors of the lung: a clinicopathologic analysis of 10 cases.Am J SurgPathol. 2015 Jun;39(6):753-60. doi: 10.1097/PAS.0000000000000414.[pubmed]
6. Lau KW, Aubry MC, Tan GS, Lim CH, Takano AM.Ciliated muconodular papillary tumor: a solitary peripheral lung nodule in a teenage girl.Hum Pathol. 2016 Mar;49:22-6.doi: 10.1016/j.humpath.2015.09.038. Epub 2015 Oct 28.[pubmed]
7. Sato T, Koike K, Homma A, Yokoyama A. Ciliated muconodular papillary tumour of the lung: a newly defined low-grade malignant tumour.Interact Cardiovasc ThoracSurg2010; 11(5): 685–687.doi: 10.1510/icvts.2009.229989.[pubmed]
8. Arai Y, Shimizu S, Eimoto T, Shimizu S, Otsuki Y, Kobayashi H, Ogawa H, Travis WD. Peripheral pulmonary papillary/glandular neoplasms with ciliated cells and a component of well-differentiated adenocarcinoma: report of three tumours.Histopathology. 2010 Jan;56(2):265-9. doi: 10.1111/j.1365-2559.2009.03463.x.[pubmed]
2. Ishikawa M, Sumitomo S, Imamura N, Nishida T, Mineura K, Ono K. Ciliated muconodular papillary tumor of the lung: report of five cases. Journal of Surgical Case Reports 2016;8:1–4. doi: 10.1093/jscr/rjw144.[pubmed]
3. Flieder DB, Thivolet-Bejui F, Popper H. Tumor of the lung. Benign epithelial lesions. In: Travis WD, Brambilla E, Mu¨ller-Hermelink HK, Harris CC, editors. World Health Organization classification of tumors: pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press 2004:78–81.
4. Nakamura S, Koshikawa T, Sato T, Hayashi K, Suchi T.Extremely well differentiated papillary adenocarcinoma of the lung with prominent cilia formation.Acta PatholJpn. 1992 Oct;42(10):745-50.[pubmed]
5. Kamata T, Yoshida A, Kosuge T, Watanabe S, Asamura H, Tsuta K. Ciliated muconodular papillary tumors of the lung: a clinicopathologic analysis of 10 cases.Am J SurgPathol. 2015 Jun;39(6):753-60. doi: 10.1097/PAS.0000000000000414.[pubmed]
6. Lau KW, Aubry MC, Tan GS, Lim CH, Takano AM.Ciliated muconodular papillary tumor: a solitary peripheral lung nodule in a teenage girl.Hum Pathol. 2016 Mar;49:22-6.doi: 10.1016/j.humpath.2015.09.038. Epub 2015 Oct 28.[pubmed]
7. Sato T, Koike K, Homma A, Yokoyama A. Ciliated muconodular papillary tumour of the lung: a newly defined low-grade malignant tumour.Interact Cardiovasc ThoracSurg2010; 11(5): 685–687.doi: 10.1510/icvts.2009.229989.[pubmed]
8. Arai Y, Shimizu S, Eimoto T, Shimizu S, Otsuki Y, Kobayashi H, Ogawa H, Travis WD. Peripheral pulmonary papillary/glandular neoplasms with ciliated cells and a component of well-differentiated adenocarcinoma: report of three tumours.Histopathology. 2010 Jan;56(2):265-9. doi: 10.1111/j.1365-2559.2009.03463.x.[pubmed]
How to Cite
Dr. Shaymaa Ahmed Sadek, Dr. Nazima Haider, & Dr. Sohaila Fatima. (2018). Diagnostic challenge of follicular thyroid carcinoma with insular component mixed with follicular patterned papillary carcinoma. Tropical Journal of Pathology and Microbiology, 4(6), 427-430. Retrieved from https://pathology.medresearch.in/index.php/jopm/article/view/191
Section
Case Report
OAI - Open Archives Initiative
