Two cases of spindle cell carcinoma with a histopathological review of biphasic tumours of head and neck
Keywords:
Spindle cell carcinoma, Head and neck, Biphasic tumours
Abstract
Spindle cell carcinoma (SPCC) is a very rare and unique biphasic variant of squamous cell carcinoma (SCC) which is a very rare malignancy of head and neck region.Spindle cell tumours are challenging feature of head and neck pathology because of different types of spindle cell lesions occurring which can be reactive to benign to malignant and very aggressive.We present here two rare cases of SPCC one involving the nasal cavity in a 38 year female and other a very aggressive maxillary sinus tumour in a 60 year male and discuss its differential diagnosis with an emphasis on biphasic tumours of head and neck.
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References
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2. Leventon GS, Evans HL.Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck: a clinicopathologic study of 20 cases. Cancer. 1981 Aug 15;48(4):994-1003.[pubmed]
3. Thompson LD, Wieneke JA, Miettinen M, Heffner DK.Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases.Am J SurgPathol. 2002 Feb;26(2):153-70.[pubmed]
4. Howard SN, Bond WR, Hong IS, Foss RD. Right maxillary sinus sarcomatoid carcinoma (sarcomatoid/spindle cell carcinoma). Otolaryngol Head Neck Surg. 2007;137 (2):355-57.doi:10.1016/j.otohns.2007.03.002.
5. Lewis JS Jr. Spindle cell lesions--neoplastic or non-neoplastic?: spindle cell carcinoma and other atypical spindle cell lesions of the head and neck. Head Neck Pathol. 2008 Jun;2(2):103-10. doi: 10.1007/s12105-008-0055-4. Epub 2008 May 28.[pubmed]
6. Lewis JE, Olsen KD, Sebo TJ.Spindle cell carcinoma of the larynx: review of 26 cases including DNA content and immunohistochemistry. Hum Pathol. 1997 Jun;28(6):664-73.[pubmed]
7. Ellis GL, Langloss JM, Heffner DK, Hyams VJ. Spindle-cell carcinoma of the aerodigestive tract. An immunohistochemical analysis of 21 cases. Am J SurgPathol. 1987 May;11(5):335-42.[pubmed]
8. Choi HR, Sturgis EM, Rosenthal DI, Luna MA, Batsakis JG, El-Naggar AK.Sarcomatoid carcinoma of the head andneck: molecular evidence for the evolutionand progression from conventional squamouscell carcinoma. Am J SurgPathol.2003;27 (9):1216-20.[pubmed]
9. Fisher C. Immunohistochemistry in diagnosis of soft tissue tumours. Histopathology. 2011 Jun;58(7):1001-12. doi: 10.1111/j.1365-2559.2010.03707.x.Epub 2010 Dec 10.[pubmed]
10. Furuta Y, Nojima T, TerakuraN,Fukuda S, Inuyama Y. A rare case of carcinosarcoma of the maxillary sinus with osteosarcomatous differentiation. Auris Nasus Larynx. 2001; 28(S): 127–29.
11. Gupta R, Singh S, Hedau S, Nigam S, Das BC, Singh I, Mandal AK. Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis. J Clin Pathol. 2007 May;60(5):472-5. Epub 2006 May 26.[pubmed]
12. Iqbal MS, Paleri V, Brown J, Greystoke A, Dobrowsky W Kelly C, Kovarik J. Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients. Ecancermedicalscience. 2015 Nov 18;9:594. doi: 10.3332/ecancer.2015.594. eCollection 2015.[pubmed]
13. Alem HB, AlNoury MK. Management of spindle cell carcinoma of the maxillary sinus: a case report and literature review. Am J Case Rep. 2014 Oct 24;15:454-8. doi: 10.12659/AJCR.891007.[pubmed]
CITATION
DOI: 10.17511/jopm.2018.i04.08
Published: 2018-08-31
How to Cite
Dr. Nihal Mirza, Dr. Nazima Haider, & Dr. Sohaila Fatima. (2018). Two cases of spindle cell carcinoma with a histopathological review of biphasic tumours of head and neck. Tropical Journal of Pathology and Microbiology, 4(4), 344-348. https://doi.org/10.17511/jopm.2018.i04.08
Section
Case Report
OAI - Open Archives Initiative
