Study of fine needle aspiration cytology of lymphadenopathy in tertiary care centre of Ahmedabad, Gujarat

  • Dr. Renu I. Sharma Assistant Professor, Department of Pathology, SMMH Medical College (Rajkiya Medical College), Saharanpur, U.P., India
  • Dr. Chetankumar M. Dharaiya Associate Professor, Department of Pathology, GMERS Medical College, Sola-Ahmedabad, Gujarat, India
Keywords: Fine needle aspiration cytology (FNAC), Lymph node, lymphadenopathy, tuberculous lymphadenitis

Abstract

Introduction: Lymph nodes are a site for organized collections of lympho-reticular tissue and are pink gray bean shaped encapsulated organs. Lymphadenopathy is one of the most common clinical presentations of patients attending the outpatient department. Lymph nodes are among the commonly aspirated organs for diagnostic purposes. Fine-needle aspiration cytology (FNAC) is a clinical technique used to obtain cells, tissues and/or fluid through a thin needle attached with disposable syringe for the purpose of diagnosis of masses.

Aims and Objectives: The aims of this study is to find out the frequency of lymphadenopathy, etiological factors and cyto-morphologial features in different age groups and incidence of various lymph node diseases on fine-needle aspiration cytology (FNAC) and to analyze the utility and diagnostic importance of FNAC in lymph node diseases.

Materials and Methods: The present study was carried out in Department of Pathology at GMERS Medical College, Sola-Ahmedabad, Gujarat a Tertiary Care Centre.A total of 268 patients of all age groups underwent FNAC of enlarged lymph nodes during this study period.

Results: Tuberculous lymphadenitis was recorded as the most common presentation of lymphadenopathy in the cervical region. Male to female ratio is 1:1.13. Most common causes of lymphadenopathy in 11-40 years age group was tubercular lymphadenitis and metastatic carcinoma in patients >50 years of age.

Conclusion: FNAC of lymph nodes is an excellent first line investigation to determine the nature of lesion. It is quick, safe, minimally invasive, and reliable and is readily accepted by the patient.

Downloads

Download data is not yet available.

References

1. Cohen MB, Miller TR, Bottles K. Classics in cytology: note on fine needle aspiration of the lymphatic glands in sleeping sickness. Acta Cytol. 1986 Jul-Aug;30(4):451-2. [PubMed]

2. Mohanty R, Wilkinson A. Utility of Fine Needle Aspiration Cytology of Lymph nodes. IOSR Journal of Dental and Medical Sciences 2013;8(5):13-8.

3. Guthrie CG. Gland puncture as a diagnostic measure. John Hopkins Bull 1921;32:266-9.

4. Orell SR, Sterrett GF, Walters MN, Whitaker D. Introduction: Manual and atlas of fine needle aspiration cytology, 3rdedi. New York: Churchill Livingstone;1999. P. 2-16.

5. Wu M, Burstein DE. Fine needle aspiration. Cancer Invest. 2004;22(4):620-8. [PubMed]

6. Simo R, Leslie A. Differential diagnosis and management of neck lumps. Surg Int 2008;74:312-22. doi.org/10.1053/j.mpsur.2006.07.006

7. Pandit AA, Candes FP, Khubchandani SR. Fine needle aspiration cytology of lymph nodes. J Postgrad Med. 1987 Jul;33(3):134-6. [PubMed]

8. Vimal S. Dharwadkar A, Chandanwale SS, Vishwanathan V, Kumar H. Cytomorphological study of lymph node lesions: A study of 187 cases. Med J D Y Patil Univ2016;9:43-50. doi: 1987/33/3/134/5275

9. Pavithra P, Geetha JP. Role of fine needle aspiration cytology in the evaluation of the spectrum of lymph node lesions. Int J Pharm Bio Sci 2014;5:377-84. doi:10.17511/jopm.2017.i3.22.

10. Kochchar Ak, Duggal G, Singh K, Kochchhar SK. Spectrum of cytological findings in patients with lymphadenopathy in rural population of South Haryana, India – Experience in a tertiary care hospital. Internet J Pathol2012;13:8.

11. Behm FG, O'Dowd GJ, Frable WJ. Fine-needle aspiration effects on benign lymph node histology. Am J Clin Pathol. 1984 Aug;82(2):195-8. [PubMed]

12. Gupta AK, Nayar M, Chandra M. Reliability and limitations of fine needle aspiration cytology of lymphadenopathies. An analysis of 1,261 cases. Acta Cytol. 1991 Nov-Dec;35(6):777-83. [PubMed]

13. Steel BL, Schwartz MR, Ramzy I. Fine needle aspiration biopsy in the diagnosis of lymphadenopathy in 1,103 patients. Role, limitations and analysis of diagnostic pitfalls. Acta Cytol. 1995 Jan-Feb;39(1):76-81.

14. Hirachand S, Lakhey M, Akhter J, et al. Evaluation of fine needle aspiration cytology of lymph nodes in Kathmandu Medical College, Teaching hospital. Kathmandu Univ Med J (KUMJ). 2009 Apr-Jun;7(26):139-42. [PubMed]

15. Hemalatha A, Udaya Kumar M, Harendra Kumar ML. Fine needle aspiration cytology of lymphnodes: A mirror in the diagnosis of spectrum of lymphnode lesions. J Clin Biomed Sci 2011;1:164-72. doi:10.17511/jopm.2017.i3.22.

16. Gupta S, Rajak CL, Sood BP, Gulati M, Rajwanshi A, Suri S. Sonographically guided fine needle aspiration biopsy of abdominal lymph nodes: Experience in 102 patients. J Ultrasound Med 1999;18:135-9. PMID : 10206806

17. Badge SA, Oyhal AG, Azad K, Meshram AT. Study of fine needle aspiration cytology of lymphnode in rural area of Bastar District, Chhattisgarh. Med J D Y Patil Univ2017;10:143-8. DOI: 10.4103/0975-2870.202097

18. Patra AK, Nanda BK, Mohapatra BK, et al. Diagnosis of lymphadenopathy by fine needle aspiration cytology. Indian J PatholMicrobiol. 1983 Oct;26(4):273-8.

19. Raghuveer CV, Pai MR, Manohar C. Role of FNAC in disorders of lymph nodes. J Cytol1996;13:45-9.

20. Mittal P, Handa U, Mohan H, et al. Comparative evaluation of fine needle aspiration cytology, culture, and PCR in diagnosis of tuberculous lymphadenitis. DOI:10.1002/dc.21472

21. Khajuria R, Goswami KC, Singh K, Dubey VK. Pattern of lymphadenopathy on fine needle aspiration cytology in Jammu. JK Sci 2006;8:157-9.

22. Arul P, Masilamani S, Akshatha C. Diagnostic efficacy of fine needle aspiration cytology in the evaluation of cervical lymphadenopathy. J Sci Soc 2016;43:117-21. DOI: 10.4103/0974-5009.190519.

23. Ng WF, Kung RT. Clinical research pathology of tuberculous lymphadenitis. A fine needle aspiration approach. J Honk Kong Med Assoc1990;42:18-21. DOI: 10.18410/jebmh/2017/829

24. Ahmed SS, Akhtar S, Akhtar K, Naseem S, Mansoor T, Khalil S. Incidence of tuberculosis from study of fine needle aspiration cytology in lymphadenopathy and acid fast staining. Indian J Community Med 2005;30:63-6.

25. Khan AH, Hayat AS, Baloch GH, Jaffery MH, Soomro MA, Siddiqui S. Study of FNAC in cervical lymphadenopathy. World Appl Sci 2011;12:1951-4.

26. Javed M. Diagnostic value of FNAC in cervical lymphadenopathy. J Postgrad Med Inst 2006;20:117-20.

27. Patel MM, Italiya SL, Dhandha ZB, Dudhat RB, Kaptan KR, Shah MB et al. Study of metastasis in lymphnodes in FNAC: Our institutional experience. Int J Res Med Sci 2013;1:451-4. DOI: 10.5455/2320-6012.ijrms20131128.

28. Ghartimagar D, Ghosh A, Ranabhat S, Shrestha MK, Narasimhan R, Talwar OP. Utility of fine needle aspiration cytology in metastatic lymph nodes. J Pathol Nepal 2011;1:92-5.

29. Bhavani C, Neeraja M, Varalakshmi KP, Ramana Babu PV, Chaitanya B, Sravani P. Role of FNAC in the diagnosis of cervical lymphadenopathy. Int J Med Res Rev 2014;2:599-603. doi:10.17511/ijmrr.2014.i06.015.

30. Joshi U, Modi B, Yadav S. A study on prevalence of chewing form of tobacco and existing quitting patterns in urban population of jamnagar, gujarat. doi: 10.4103/0970-0218.62560.

31. Shrivastava JP, Shrivastava A, Singh S. Role of FNAC in the evaluation of cervical lymphnodes: A hospital based study. J Evolution Med and Dent Sci 2015;4:9643-8. DOI: 10.14260/jemds/2015/1391.
Study of fine needle aspiration cytology of lymphadenopathy in tertiary care centre of Ahmedabad, Gujarat
CITATION
DOI: 10.17511/jopm.2018.i03.04
Published: 2018-07-31
How to Cite
Dr. Renu I. Sharma, & Dr. Chetankumar M. Dharaiya. (2018). Study of fine needle aspiration cytology of lymphadenopathy in tertiary care centre of Ahmedabad, Gujarat. Tropical Journal of Pathology and Microbiology, 4(3), 258-264. https://doi.org/10.17511/jopm.2018.i03.04
Section
Original Article