Correlation of serological markers with haematological parameters in early diagnosis of dengue infection in dengue prone areas
Background: Dengue is a serious, rapidly spreading tropical mosquito-borne viral disease caused by dengue virus belonging to the family flaviviridae and genus flavivirus in the last five decades. In many dengue endemic remote areas with limited laboratory diagnostic services their rapid diagnostic tests are simple method which provides the immediate diagnosis and early management.
Materials and methods: The study includes clinically suspected 1236 cases with all haematological parameters and tested at clinical laboratory in which 500 serum samples showed positivity for one or more markers like NS1, IgM or IgG antibodies.
Results: In our study among 500 seropositive cases thrombocytopenia (<1 lakh) was evident in 66.7% and in 736 seronegative cases thrombocytopenia was seen in 27.47%. Out of 323 NS1 positive cases, thrombocytopenia was evident in 56.0% and in exclusive antibody positive cases thrombocytopenia was noted in 19.2%. These associations were considered to be statistically significant.
Conclusion: The problem of dengue is complex in India because large population, poor medical and diagnostic facilities and inadequate mosquito control. Therefore, studies like this will significantly contribute to the early diagnosis, management and can reduce patient’s morbidity and mortality.
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