An aggressive tumor in parotid gland
Abstract
Non Hodgkin Lymphoma (NHL) of salivary gland (SG) is rare with an incidence of 2-5%. We describe a stage III, high grade NHL of parotid gland in a background of benign lymphoepithelial lesions. A 54 year female presented with a right side facial mass since 6 months. Fine needle aspiration cytology (FNAC) suggested a lymphoproliferative disorder and superficial parotidectomy was done. Histopathology and immunohistochemistry (IHC) revealed an extranodal marginal zone NHL with transformation to high grade diffuse large B cell lymphoma. SG lymphoma should be considered in elderly and IHC helps in prognostication and treatment protocols.
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References
2. Cheuk W, Chan JK. Salivary gland tumors. In: Fletcher CD, editor. Diagnostic histopathology of tumors. 3rd ed. Philadelphia: Churchill Livingstone Elsevier; 2007,7:239-325.
3. Barnes L., Eveson J. W., Reichart P., Sidransky D., Tumours of the salivary glands, World Health Organization Classification of Tumours, Pathology and Genetics of Head and Neck Tumours, IARC Press, Lyon, 2005,5:209–281.
4. Konofaos P, Spartalis E, Katsaronis P, Kouraklis G. Primary parotid gland lymphoma: a case report.J Med Case Rep. 2011 Aug 15;5:380. doi: 10.1186/1752-1947-5-380. [PubMed]
5. Boyd SD, Natkunam Y, Allen JR, Warnke RA. Selective immunophenotyping for diagnosis of B-cell neoplasms: immunohistochemistry and flow cytometry strategies and results.ApplImmunohistochemMolMorphol. 2013 Mar;21(2):116-31. doi: 10.1097/PAI.0b013e31825d550a.
6. Yamamoto Y, Yamochi-Onizuka T, Shiozawa E, Kushima M, Nakamaki T, Tomoyasu S, Kaneko K, Mitamura K, Hoshino M, Ishii H, Kusano M, Ota H. Discordant lymphoma: MALT lymphoma of the stomach and follicular lymphoma of the parotid gland.Pathol Int. 2003 Aug;53(8):557-62. [PubMed]
7. Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma.Cancer. 1983 Oct 15;52(8):1410-6.
8. Shidnia H, Hornback NB, Lingeman R, Barlow P. Extranodal lymphoma of the head and neck area. Am J ClinOncol. 1985 Jun;8(3):235-43.
9. Kalpadakis C, Pangalis GA, Vassilakopoulos TP, et al: Non-gastric extra-nodal marginal zone lymphomas: A single centre experience on 76 patients.Leuk Lymphoma. 2008 Dec;49(12):2308-15. doi: 10.1080/10428190802510331. [PubMed]
10. Peng F, Guo L, Yao WK, Zheng Y, Liu Y, Duan XM, Wang Y. Identification of prognostic factors in patients with diffuse large B-cell lymphoma.Indian J PatholMicrobiol. 2017 Jan-Mar;60(1):87-91. doi: 10.4103/0377-4929.200056. [PubMed]
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